BRD-K20168484_1h-indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)- [cas]_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K20168484_1h-indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)- [cas]_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COMP cartilage oligomeric matrix protein
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYB561 cytochrome b561
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FBN1 fibrillin 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
G0S2 G0/G1 switch 2
GRB14 growth factor receptor-bound protein 14
GSTZ1 glutathione S-transferase zeta 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IARS isoleucyl-tRNA synthetase
KIAA0753 KIAA0753
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KYNU kynureninase
MAP1B microtubule-associated protein 1B
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PIP prolactin-induced protein
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PTCH1 patched 1
PTX3 pentraxin 3, long
S100P S100 calcium binding protein P
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SRGN serglycin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOX3 TOX high mobility group box family member 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UFM1 ubiquitin-fold modifier 1
XBP1 X-box binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ALOX5 arachidonate 5-lipoxygenase
BACE2 beta-site APP-cleaving enzyme 2
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CALR calreticulin
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CRABP1 cellular retinoic acid binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCK deoxycytidine kinase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HSPA1A heat shock 70kDa protein 1A
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
NDFIP1 Nedd4 family interacting protein 1
NT5DC2 5'-nucleotidase domain containing 2
POU2AF1 POU class 2 associating factor 1
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RFC2 replication factor C (activator 1) 2, 40kDa
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNX10 sorting nexin 10
SOX11 SRY (sex determining region Y)-box 11
SPON1 spondin 1, extracellular matrix protein
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB2 tribbles pseudokinase 2
TRIP13 thyroid hormone receptor interactor 13
TYMP thymidine phosphorylase
UBQLN2 ubiquilin 2
Funding