BRD-K20285085_fostamatinib_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K20285085_fostamatinib_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARG2 arginase 2
ATRX alpha thalassemia/mental retardation syndrome X-linked
AURKA aurora kinase A
CCL5 chemokine (C-C motif) ligand 5
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMXL2 Dmx-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
FOS FBJ murine osteosarcoma viral oncogene homolog
IGHM immunoglobulin heavy constant mu
KRT15 keratin 15, type I
MT1H metallothionein 1H
MT1X metallothionein 1X
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NELL2 NEL-like 2 (chicken)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PLCB4 phospholipase C, beta 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SNX10 sorting nexin 10
TCL1A T-cell leukemia/lymphoma 1A
TGFA transforming growth factor, alpha
TNPO1 transportin 1

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CALD1 caldesmon 1
CCNF cyclin F
CD200 CD200 molecule
CD58 CD58 molecule
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CKAP4 cytoskeleton-associated protein 4
COL1A2 collagen, type I, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL8 chemokine (C-X-C motif) ligand 8
DEPTOR DEP domain containing MTOR-interacting protein
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP7 fatty acid binding protein 7, brain
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HES1 hes family bHLH transcription factor 1
HIST1H4C histone cluster 1, H4c
HOXC6 homeobox C6
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI6 interferon, alpha-inducible protein 6
IFITM2 interferon induced transmembrane protein 2
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3 lectin, galactoside-binding, soluble, 3
MAPT microtubule-associated protein tau
MDK midkine (neurite growth-promoting factor 2)
MGP matrix Gla protein
MXI1 MAX interactor 1, dimerization protein
NREP neuronal regeneration related protein
PEG10 paternally expressed 10
PI3 peptidase inhibitor 3, skin-derived
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLSCR4 phospholipid scramblase 4
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSPH phosphoserine phosphatase
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNASE4 ribonuclease, RNase A family, 4
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SGCE sarcoglycan, epsilon
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SRSF6 serine/arginine-rich splicing factor 6
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TMC5 transmembrane channel-like 5
TMEM38B transmembrane protein 38B
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2
ZDHHC6 zinc finger, DHHC-type containing 6
Funding