BRD-K20285085_fostamatinib_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K20285085_fostamatinib_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARMCX2 armadillo repeat containing, X-linked 2
BCHE butyrylcholinesterase
CA12 carbonic anhydrase XII
CD36 CD36 molecule (thrombospondin receptor)
COL1A2 collagen, type I, alpha 2
CTSE cathepsin E
CXCL6 chemokine (C-X-C motif) ligand 6
EPS8 epidermal growth factor receptor pathway substrate 8
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
FRZB frizzled-related protein
GJA1 gap junction protein, alpha 1, 43kDa
HIST1H2AC histone cluster 1, H2ac
HP haptoglobin
MAN2A1 mannosidase, alpha, class 2A, member 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PRDX2 peroxiredoxin 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCGB2A2 secretoglobin, family 2A, member 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SYT1 synaptotagmin I
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
WASL Wiskott-Aldrich syndrome-like

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA1 annexin A1
ANXA3 annexin A3
ATF3 activating transcription factor 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL9A3 collagen, type IX, alpha 3
CSTA cystatin A (stefin A)
CYR61 cysteine-rich, angiogenic inducer, 61
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM171A1 family with sequence similarity 171, member A1
FAM57A family with sequence similarity 57, member A
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GFOD1 glucose-fructose oxidoreductase domain containing 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HEG1 heart development protein with EGF-like domains 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGFBP7 insulin-like growth factor binding protein 7
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
MTSS1 metastasis suppressor 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PDGFA platelet-derived growth factor alpha polypeptide
PLAGL1 pleiomorphic adenoma gene-like 1
PMP22 peripheral myelin protein 22
PRSS23 protease, serine, 23
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTRF polymerase I and transcript release factor
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A10 S100 calcium binding protein A10
SFN stratifin
TNS3 tensin 3
TOX thymocyte selection-associated high mobility group box
TPM1 tropomyosin 1 (alpha)
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
Funding