BRD-K20285085_fostamatinib_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K20285085_fostamatinib_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ASS1 argininosuccinate synthase 1
AURKA aurora kinase A
C14ORF132 chromosome 14 open reading frame 132
CCNB2 cyclin B2
CCNG1 cyclin G1
CD24 CD24 molecule
CDC25B cell division cycle 25B
CLGN calmegin
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DAPK1 death-associated protein kinase 1
EGR1 early growth response 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GPRC5B G protein-coupled receptor, class C, group 5, member B
HSPA8 heat shock 70kDa protein 8
ITGA6 integrin, alpha 6
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
MAL mal, T-cell differentiation protein
MAMLD1 mastermind-like domain containing 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NXF3 nuclear RNA export factor 3
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB4A RAB4A, member RAS oncogene family
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPAG5 sperm associated antigen 5
STXBP1 syntaxin binding protein 1
TWIST1 twist family bHLH transcription factor 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
ZIC1 Zic family member 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARG1 arginase 1
ASPN asporin
BGN biglycan
BID BH3 interacting domain death agonist
C10ORF10 chromosome 10 open reading frame 10
CD200 CD200 molecule
CD58 CD58 molecule
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CLDND1 claudin domain containing 1
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
DPYSL3 dihydropyrimidinase-like 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FKBP14 FK506 binding protein 14, 22 kDa
HOXA5 homeobox A5
IFITM1 interferon induced transmembrane protein 1
IFNGR1 interferon gamma receptor 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP5 insulin-like growth factor binding protein 5
INHBA inhibin, beta A
KRT6A keratin 6A, type II
LIPG lipase, endothelial
LRRC17 leucine rich repeat containing 17
MCM6 minichromosome maintenance complex component 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSH6 mutS homolog 6
NAMPT nicotinamide phosphoribosyltransferase
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RPS5 ribosomal protein S5
SCGB1D2 secretoglobin, family 1D, member 2
SORBS2 sorbin and SH3 domain containing 2
SORD sorbitol dehydrogenase
SPEN spen family transcriptional repressor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS2 thrombospondin 2
TMEM45A transmembrane protein 45A
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAM1 vascular cell adhesion molecule 1
Funding