BRD-K20285085_fostamatinib_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K20285085_fostamatinib_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BST2 bone marrow stromal cell antigen 2
CGA glycoprotein hormones, alpha polypeptide
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
FBXO11 F-box protein 11
GARS glycyl-tRNA synthetase
IFI30 interferon, gamma-inducible protein 30
IGFBP5 insulin-like growth factor binding protein 5
ISYNA1 inositol-3-phosphate synthase 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
S100P S100 calcium binding protein P
VCAN versican

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
ANOS1 anosmin 1
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
CLIC5 chloride intracellular channel 5
CRABP1 cellular retinoic acid binding protein 1
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
DOCK4 dedicator of cytokinesis 4
EDNRB endothelin receptor type B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FOSL1 FOS-like antigen 1
GPM6B glycoprotein M6B
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXA10 homeobox A10
IGF1 insulin-like growth factor 1 (somatomedin C)
IL32 interleukin 32
JUN jun proto-oncogene
KIAA0226L KIAA0226-like
KIAA1033 KIAA1033
LTF lactotransferrin
MEIS1 Meis homeobox 1
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
PAWR PRKC, apoptosis, WT1, regulator
PDLIM5 PDZ and LIM domain 5
PELI1 pellino E3 ubiquitin protein ligase 1
PRUNE2 prune homolog 2 (Drosophila)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RND3 Rho family GTPase 3
SERINC5 serine incorporator 5
SFN stratifin
SOX9 SRY (sex determining region Y)-box 9
TBX2 T-box 2
TUBB2B tubulin, beta 2B class IIb
Funding