BRD-K20526256_HG-14-10-04_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-K20526256_HG-14-10-04_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHR aryl hydrocarbon receptor
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOA aldolase A, fructose-bisphosphate
ARMCX2 armadillo repeat containing, X-linked 2
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
ATXN7L3B ataxin 7-like 3B
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BZW2 basic leucine zipper and W2 domains 2
C14ORF132 chromosome 14 open reading frame 132
CADPS2 Ca++-dependent secretion activator 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC16 cell division cycle 16
CDK19 cyclin-dependent kinase 19
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CFD complement factor D (adipsin)
CHMP1B charged multivesicular body protein 1B
CNN1 calponin 1, basic, smooth muscle
COL1A1 collagen, type I, alpha 1
COLEC12 collectin sub-family member 12
CSRP1 cysteine and glycine-rich protein 1
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSK cathepsin K
CTTN cortactin
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEPTOR DEP domain containing MTOR-interacting protein
DUSP6 dual specificity phosphatase 6
EIF4B eukaryotic translation initiation factor 4B
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADS1 fatty acid desaturase 1
FAM46A family with sequence similarity 46, member A
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FNBP1 formin binding protein 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS1 growth arrest-specific 1
GAS6 growth arrest-specific 6
GBP2 guanylate binding protein 2, interferon-inducible
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
GSTA4 glutathione S-transferase alpha 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
HSPA2 heat shock 70kDa protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFITM1 interferon induced transmembrane protein 1
IFT57 intraflagellar transport 57
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
KDSR 3-ketodihydrosphingosine reductase
KIAA1598
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LETMD1 LETM1 domain containing 1
LGALS4 lectin, galactoside-binding, soluble, 4
LINC00341 long intergenic non-protein coding RNA 341
LMCD1 LIM and cysteine-rich domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MAN1A1 mannosidase, alpha, class 1A, member 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MPDZ multiple PDZ domain protein
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MXRA5 matrix-remodelling associated 5
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPDC1 neural proliferation, differentiation and control, 1
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PDGFRL platelet-derived growth factor receptor-like
PERP PERP, TP53 apoptosis effector
PHGDH phosphoglycerate dehydrogenase
PLCB4 phospholipase C, beta 4
PLSCR3 phospholipid scramblase 3
PRAF2 PRA1 domain family, member 2
PRKCI protein kinase C, iota
PRNP prion protein
R3HDM2 R3H domain containing 2
RBKS ribokinase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A14 S100 calcium binding protein A14
SAMD4A sterile alpha motif domain containing 4A
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC22A18 solute carrier family 22, member 18
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPATA2L spermatogenesis associated 2-like
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQLE squalene epoxidase
SSPN sarcospan
STC1 stanniocalcin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SVIL supervillin
TAPBPL TAP binding protein-like
TCEAL4 transcription elongation factor A (SII)-like 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TMC5 transmembrane channel-like 5
TNS1 tensin 1
TPBG trophoblast glycoprotein
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
TXNIP thioredoxin interacting protein
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
ATAD2 ATPase family, AAA domain containing 2
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALR calreticulin
CCNA2 cyclin A2
CCNC cyclin C
CCND3 cyclin D3
CD48 CD48 molecule
CD9 CD9 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CYTL1 cytokine-like 1
DCK deoxycytidine kinase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSE dermatan sulfate epimerase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
EPHA3 EPH receptor A3
FABP4 fatty acid binding protein 4, adipocyte
FSCN1 fascin actin-bundling protein 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GTSE1 G-2 and S-phase expressed 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HILPDA hypoxia inducible lipid droplet-associated
HJURP Holliday junction recognition protein
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
KCTD12 potassium channel tetramerization domain containing 12
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAPTM5 lysosomal protein transmembrane 5
LPL lipoprotein lipase
LRMP lymphoid-restricted membrane protein
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPPED2 metallophosphoesterase domain containing 2
MT1M metallothionein 1M
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NEK2 NIMA-related kinase 2
PAK1IP1 PAK1 interacting protein 1
PBK PDZ binding kinase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RBM38 RNA binding motif protein 38
RPA3 replication protein A3, 14kDa
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHCBP1 SHC SH2-domain binding protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC35F2 solute carrier family 35, member F2
SRGN serglycin
TACC1 transforming, acidic coiled-coil containing protein 1
TCL1A T-cell leukemia/lymphoma 1A
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VDAC1 voltage-dependent anion channel 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF22 zinc finger protein 22
Funding