BRD-K20696416_NVP-AEW541_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K20696416_NVP-AEW541_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ANOS1 anosmin 1
AQP3 aquaporin 3 (Gill blood group)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFD complement factor D (adipsin)
CLEC2B C-type lectin domain family 2, member B
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
FBN2 fibrillin 2
FHL1 four and a half LIM domains 1
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXA5 homeobox A5
IGFBP5 insulin-like growth factor binding protein 5
KIF14 kinesin family member 14
KLK11 kallikrein-related peptidase 11
LGALS1 lectin, galactoside-binding, soluble, 1
LIPG lipase, endothelial
METTL7A methyltransferase like 7A
MYH11 myosin, heavy chain 11, smooth muscle
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIB nuclear factor I/B
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PER1 period circadian clock 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SETBP1 SET binding protein 1
SPARCL1 SPARC-like 1 (hevin)
SRSF6 serine/arginine-rich splicing factor 6
TFF3 trefoil factor 3 (intestinal)
TPM2 tropomyosin 2 (beta)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
CCR7 chemokine (C-C motif) receptor 7
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFNB2 ephrin-B2
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
LTF lactotransferrin
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
POSTN periostin, osteoblast specific factor
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
RAI14 retinoic acid induced 14
RPL39L ribosomal protein L39-like
SCG2 secretogranin II
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPEN spen family transcriptional repressor
SRSF7 serine/arginine-rich splicing factor 7
TOX3 TOX high mobility group box family member 3
VTCN1 V-set domain containing T cell activation inhibitor 1
Funding