BRD-K20742498_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K20742498_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACA acetyl-CoA carboxylase alpha
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
AMACR alpha-methylacyl-CoA racemase
ANKRD10 ankyrin repeat domain 10
BEX1 brain expressed, X-linked 1
CD24 CD24 molecule
CD9 CD9 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLIC4 chloride intracellular channel 4
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST3 cystatin C
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DMXL2 Dmx-like 2
DUSP4 dual specificity phosphatase 4
EIF5A eukaryotic translation initiation factor 5A
EPHB2 EPH receptor B2
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOXO3 forkhead box O3
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GSTA4 glutathione S-transferase alpha 4
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LIPG lipase, endothelial
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MACF1 microtubule-actin crosslinking factor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCTP1 multiple C2 domains, transmembrane 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NPC2 Niemann-Pick disease, type C2
PDLIM5 PDZ and LIM domain 5
PRDX2 peroxiredoxin 2
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOB ras homolog family member B
RNF167 ring finger protein 167
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOCS2 suppressor of cytokine signaling 2
SQLE squalene epoxidase
SYNE2 spectrin repeat containing, nuclear envelope 2
TLR4 toll-like receptor 4
TMEM176B transmembrane protein 176B
TOX3 TOX high mobility group box family member 3
TRBC1 T cell receptor beta constant 1
VCAN versican
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCTD dCMP deaminase
DKK1 dickkopf WNT signaling pathway inhibitor 1
ECM1 extracellular matrix protein 1
EDNRA endothelin receptor type A
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FCGBP Fc fragment of IgG binding protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INHBB inhibin, beta B
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LOX lysyl oxidase
MUC4 mucin 4, cell surface associated
NIT1 nitrilase 1
PAM peptidylglycine alpha-amidating monooxygenase
POSTN periostin, osteoblast specific factor
PRKCD protein kinase C, delta
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RIPK4 receptor-interacting serine-threonine kinase 4
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SELENBP1 selenium binding protein 1
SFRP1 secreted frizzled-related protein 1
SMYD2 SET and MYND domain containing 2
SNAI2 snail family zinc finger 2
SNX7 sorting nexin 7
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSKU tsukushi, small leucine rich proteoglycan
TUSC3 tumor suppressor candidate 3
Funding