BRD-K20755323_-666_A549_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K20755323_-666_A549_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CALU calumenin
CAV1 caveolin 1, caveolae protein, 22kDa
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLIC4 chloride intracellular channel 4
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CTSH cathepsin H
CXCL3 chemokine (C-X-C motif) ligand 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DFNA5 deafness, autosomal dominant 5
EGR1 early growth response 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPAS1 endothelial PAS domain protein 1
FAM171A1 family with sequence similarity 171, member A1
FHL1 four and a half LIM domains 1
FKBP11 FK506 binding protein 11, 19 kDa
FXYD3 FXYD domain containing ion transport regulator 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HDLBP high density lipoprotein binding protein
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LAMB3 laminin, beta 3
LAMP3 lysosomal-associated membrane protein 3
LARP6 La ribonucleoprotein domain family, member 6
LHFPL2 lipoma HMGIC fusion partner-like 2
MAP1B microtubule-associated protein 1B
MARS methionyl-tRNA synthetase
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MGLL monoglyceride lipase
MOCOS molybdenum cofactor sulfurase
NAV2 neuron navigator 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAM peptidylglycine alpha-amidating monooxygenase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTGES prostaglandin E synthase
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PYGB phosphorylase, glycogen; brain
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRBP1 ribosome binding protein 1
RTN1 reticulon 1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOBP sine oculis binding protein homolog (Drosophila)
SOCS2 suppressor of cytokine signaling 2
SRGN serglycin
STC2 stanniocalcin 2
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SYNJ2 synaptojanin 2
TPBG trophoblast glycoprotein
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPYL5 TSPY-like 5
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
YARS tyrosyl-tRNA synthetase
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
BCL6 B-cell CLL/lymphoma 6
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF2 chromosome 14 open reading frame 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CKS2 CDC28 protein kinase regulatory subunit 2
CRYZ crystallin, zeta (quinone reductase)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDNRB endothelin receptor type B
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HES1 hes family bHLH transcription factor 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0101 KIAA0101
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBH limb bud and heart development
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKSL1 MARCKS-like 1
MSH6 mutS homolog 6
NARF nuclear prelamin A recognition factor
NDC80 NDC80 kinetochore complex component
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
PRSS23 protease, serine, 23
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SEPP1 selenoprotein P, plasma, 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCF4 transcription factor 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOP2A topoisomerase (DNA) II alpha 170kDa
TTK TTK protein kinase
TUBB4B tubulin, beta 4B class IVb
VCAN versican
VRK1 vaccinia related kinase 1
Funding