BRD-K20755323_-666_A549_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K20755323_-666_A549_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADIRF adipogenesis regulatory factor
AKR1C2 aldo-keto reductase family 1, member C2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CLDN3 claudin 3
CREB3L2 cAMP responsive element binding protein 3-like 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IARS isoleucyl-tRNA synthetase
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV3-20 immunoglobulin kappa variable 3-20
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IL6 interleukin 6
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LARP6 La ribonucleoprotein domain family, member 6
MOCOS molybdenum cofactor sulfurase
MPO myeloperoxidase
MT1M metallothionein 1M
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PER1 period circadian clock 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RAB2A RAB2A, member RAS oncogene family
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCRG1 stimulator of chondrogenesis 1
SEC31A SEC31 homolog A (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SSR4 signal sequence receptor, delta
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCEA1 transcription elongation factor A (SII), 1
TES testin LIM domain protein
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRA3 adhesion G protein-coupled receptor A3
AURKA aurora kinase A
BCHE butyrylcholinesterase
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP22 dual specificity phosphatase 22
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXOSC4 exosome component 4
FAR2 fatty acyl CoA reductase 2
FASTKD5 FAST kinase domains 5
FYB FYN binding protein
GAS2L1 growth arrest-specific 2 like 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
KIF20A kinesin family member 20A
KLK10 kallikrein-related peptidase 10
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
NMU neuromedin U
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
PRAME preferentially expressed antigen in melanoma
QPCT glutaminyl-peptide cyclotransferase
RBP1 retinol binding protein 1, cellular
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TACC3 transforming, acidic coiled-coil containing protein 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TRIM14 tripartite motif containing 14
VWA5A von Willebrand factor A domain containing 5A
WSB2 WD repeat and SOCS box containing 2
Funding