BRD-K20755323_-666_CORL23_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K20755323_-666_CORL23_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
CA2 carbonic anhydrase II
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
COL2A1 collagen, type II, alpha 1
COL6A2 collagen, type VI, alpha 2
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
FGFR1 fibroblast growth factor receptor 1
FLNA filamin A, alpha
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GSDMB gasdermin B
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIRA histone cell cycle regulator
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
JUN jun proto-oncogene
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM5D lysine (K)-specific demethylase 5D
LMO4 LIM domain only 4
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1M metallothionein 1M
MUC4 mucin 4, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NARFL nuclear prelamin A recognition factor-like
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PIR pirin (iron-binding nuclear protein)
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLAC8 placenta-specific 8
PLIN2 perilipin 2
POU2AF1 POU class 2 associating factor 1
PPAP2B phosphatidic acid phosphatase type 2B
PRKCB protein kinase C, beta
PRUNE2 prune homolog 2 (Drosophila)
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RIOK3 RIO kinase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TMPRSS2 transmembrane protease, serine 2
TXN thioredoxin
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AREG amphiregulin
ASPN asporin
CCNF cyclin F
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
E2F2 E2F transcription factor 2
FRZB frizzled-related protein
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
INHBA inhibin, beta A
INSM1 insulinoma-associated 1
ISG15 ISG15 ubiquitin-like modifier
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LAP3 leucine aminopeptidase 3
LAPTM4B lysosomal protein transmembrane 4 beta
LPAR6 lysophosphatidic acid receptor 6
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
PIP prolactin-induced protein
PLK1 polo-like kinase 1
RBP1 retinol binding protein 1, cellular
RSAD2 radical S-adenosyl methionine domain containing 2
S100A2 S100 calcium binding protein A2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLPI secretory leukocyte peptidase inhibitor
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX11 SRY (sex determining region Y)-box 11
SQLE squalene epoxidase
STOM stomatin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TKTL1 transketolase-like 1
TOX3 TOX high mobility group box family member 3
VCAM1 vascular cell adhesion molecule 1
VSNL1 visinin-like 1
XIST X inactive specific transcript (non-protein coding)
Funding