BRD-K20755323_-666_EFO27_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K20755323_-666_EFO27_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CYTIP cytohesin 1 interacting protein
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DLK1 delta-like 1 homolog (Drosophila)
EMX2 empty spiracles homeobox 2
ESM1 endothelial cell-specific molecule 1
FST follistatin
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAS GNAS complex locus
GRB10 growth factor receptor-bound protein 10
GUSBP11 glucuronidase, beta pseudogene 11
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGF1R insulin-like growth factor 1 receptor
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
KDM5A lysine (K)-specific demethylase 5A
LRP2 low density lipoprotein receptor-related protein 2
MAP7 microtubule-associated protein 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
MZB1 marginal zone B and B1 cell-specific protein
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLAGL1 pleiomorphic adenoma gene-like 1
POU2AF1 POU class 2 associating factor 1
PRKCQ protein kinase C, theta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNX13 sorting nexin 13
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR1B small proline-rich protein 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3
VCAN versican
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
APOD apolipoprotein D
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BST2 bone marrow stromal cell antigen 2
CCNF cyclin F
CHPT1 choline phosphotransferase 1
CHRDL1 chordin-like 1
CLGN calmegin
CNN3 calponin 3, acidic
CSRP2 cysteine and glycine-rich protein 2
CST1 cystatin SN
CST4 cystatin S
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FBLN1 fibulin 1
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GPM6B glycoprotein M6B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXC6 homeobox C6
IFI6 interferon, alpha-inducible protein 6
JMJD1C jumonji domain containing 1C
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MID1 midline 1
MX1 MX dynamin-like GTPase 1
NRN1 neuritin 1
PDLIM5 PDZ and LIM domain 5
PTMA prothymosin, alpha
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS4Y1 ribosomal protein S4, Y-linked 1
SFRP4 secreted frizzled-related protein 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORBS1 sorbin and SH3 domain containing 1
SOX9 SRY (sex determining region Y)-box 9
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP4 TIMP metallopeptidase inhibitor 4
TMEM100 transmembrane protein 100
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM2 tripartite motif containing 2
UBE2S ubiquitin-conjugating enzyme E2S
ZBTB18 zinc finger and BTB domain containing 18
ZNF586 zinc finger protein 586
Funding