BRD-K20755323_-666_HCC515_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K20755323_-666_HCC515_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BEX1 brain expressed, X-linked 1
CA2 carbonic anhydrase II
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COPG1 coatomer protein complex, subunit gamma 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAP death-associated protein
DDIT3 DNA-damage-inducible transcript 3
DHDDS dehydrodolichyl diphosphate synthase
DMBT1 deleted in malignant brain tumors 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DRAM1 DNA-damage regulated autophagy modulator 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FAM63A family with sequence similarity 63, member A
FKBP11 FK506 binding protein 11, 19 kDa
FKBP2 FK506 binding protein 2, 13kDa
G6PD glucose-6-phosphate dehydrogenase
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GSTA1 glutathione S-transferase alpha 1
HDLBP high density lipoprotein binding protein
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
MAGED1 melanoma antigen family D1
MANF mesencephalic astrocyte-derived neurotrophic factor
MYDGF myeloid-derived growth factor
NANS N-acetylneuraminic acid synthase
NQO1 NAD(P)H dehydrogenase, quinone 1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA3 protein disulfide isomerase family A, member 3
PDIA6 protein disulfide isomerase family A, member 6
PGM3 phosphoglucomutase 3
PPIB peptidylprolyl isomerase B (cyclophilin B)
PYCR1 pyrroline-5-carboxylate reductase 1
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SDF2L1 stromal cell-derived factor 2-like 1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC24D SEC24 family member D
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEC62 SEC62 homolog (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPP1 secreted phosphoprotein 1
STC2 stanniocalcin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM214 transmembrane protein 214
TREM1 triggering receptor expressed on myeloid cells 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
CALD1 caldesmon 1
CCND1 cyclin D1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CXADR coxsackie virus and adenovirus receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FSTL1 follistatin-like 1
GPM6B glycoprotein M6B
HES1 hes family bHLH transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITGB5 integrin, beta 5
KRT17 keratin 17, type I
LUM lumican
MCAM melanoma cell adhesion molecule
MCM6 minichromosome maintenance complex component 6
MLANA melan-A
MMP10 matrix metallopeptidase 10
MTA1 metastasis associated 1
NFIB nuclear factor I/B
NUP85 nucleoporin 85kDa
PALLD palladin, cytoskeletal associated protein
PCNA proliferating cell nuclear antigen
PMEL premelanosome protein
PODXL podocalyxin-like
RBP1 retinol binding protein 1, cellular
RELN reelin
RGS2 regulator of G-protein signaling 2
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SRPX sushi-repeat containing protein, X-linked
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TUBB4B tubulin, beta 4B class IVb
TYRP1 tyrosinase-related protein 1
Funding