BRD-K20755323_-666_HCT116_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

182 genes differentially expressed following the BRD-K20755323_-666_HCT116_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
AKR1C2 aldo-keto reductase family 1, member C2
ANXA10 annexin A10
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKAP4 cytoskeleton-associated protein 4
CLGN calmegin
CLIC4 chloride intracellular channel 4
COL1A1 collagen, type I, alpha 1
CREG1 cellular repressor of E1A-stimulated genes 1
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGFR epidermal growth factor receptor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
EVI2A ecotropic viral integration site 2A
FABP4 fatty acid binding protein 4, adipocyte
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FSTL1 follistatin-like 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP6 insulin-like growth factor binding protein 6
IGKV4-1 immunoglobulin kappa variable 4-1
INHBA inhibin, beta A
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM5D lysine (K)-specific demethylase 5D
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
KRT81 keratin 81, type II
LAMB3 laminin, beta 3
LIF leukemia inhibitory factor
LIMCH1 LIM and calponin homology domains 1
LTBP1 latent transforming growth factor beta binding protein 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MOCOS molybdenum cofactor sulfurase
MT1F metallothionein 1F
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NRP1 neuropilin 1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PPAP2B phosphatidic acid phosphatase type 2B
PPIC peptidylprolyl isomerase C (cyclophilin C)
PSAT1 phosphoserine aminotransferase 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQSTM1 sequestosome 1
SRGN serglycin
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM6SF1 transmembrane 6 superfamily member 1
TPD52 tumor protein D52
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3

decreased expression

Symbol Name
AFP alpha-fetoprotein
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ASRGL1 asparaginase like 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX1 brain expressed, X-linked 1
BZW2 basic leucine zipper and W2 domains 2
CADM1 cell adhesion molecule 1
CCL5 chemokine (C-C motif) ligand 5
CCNB2 cyclin B2
CD8A CD8a molecule
CLU clusterin
CTSC cathepsin C
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
CXCL9 chemokine (C-X-C motif) ligand 9
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FAM46A family with sequence similarity 46, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FZD5 frizzled class receptor 5
GREB1 growth regulation by estrogen in breast cancer 1
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ITGB5 integrin, beta 5
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
KLK11 kallikrein-related peptidase 11
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MEIS1 Meis homeobox 1
MXRA7 matrix-remodelling associated 7
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
QPRT quinolinate phosphoribosyltransferase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A6 S100 calcium binding protein A6
SEPT6 septin 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TARP TCR gamma alternate reading frame protein
TLE4 transducin-like enhancer of split 4
TMCC1 transmembrane and coiled-coil domain family 1
TMPO thymopoietin
TNS1 tensin 1
TSPAN13 tetraspanin 13
TTC39A tetratricopeptide repeat domain 39A
TYRP1 tyrosinase-related protein 1
VSNL1 visinin-like 1
XIST X inactive specific transcript (non-protein coding)
ZCCHC14 zinc finger, CCHC domain containing 14
Funding