BRD-K20755323_-666_HEPG2_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K20755323_-666_HEPG2_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
CHN1 chimerin 1
COL15A1 collagen, type XV, alpha 1
CRABP2 cellular retinoic acid binding protein 2
DDIT3 DNA-damage-inducible transcript 3
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
FBN2 fibrillin 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FST follistatin
GAB2 GRB2-associated binding protein 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GEM GTP binding protein overexpressed in skeletal muscle
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
ITGA6 integrin, alpha 6
JAM3 junctional adhesion molecule 3
JCHAIN joining chain of multimeric IgA and IgM
JUND jun D proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT6B keratin 6B, type II
MAP1B microtubule-associated protein 1B
MAST4 microtubule associated serine/threonine kinase family member 4
MME membrane metallo-endopeptidase
MT1F metallothionein 1F
MT1G metallothionein 1G
MYO1D myosin ID
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
TGFA transforming growth factor, alpha
THBD thrombomodulin
TRIB3 tribbles pseudokinase 3
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
VCAN versican
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANOS1 anosmin 1
AURKA aurora kinase A
BCHE butyrylcholinesterase
CCNB1 cyclin B1
CCNF cyclin F
CDKN3 cyclin-dependent kinase inhibitor 3
CHL1 cell adhesion molecule L1-like
CXCL5 chemokine (C-X-C motif) ligand 5
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EHD3 EH-domain containing 3
FASTKD5 FAST kinase domains 5
FLRT3 fibronectin leucine rich transmembrane protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLUL glutamate-ammonia ligase
HACD2 3-hydroxyacyl-CoA dehydratase 2
HBB hemoglobin, beta
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNB1 karyopherin (importin) beta 1
MEIS1 Meis homeobox 1
MRPL19 mitochondrial ribosomal protein L19
PCDH9 protocadherin 9
PDZD2 PDZ domain containing 2
PEX11A peroxisomal biogenesis factor 11 alpha
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RRM2 ribonucleotide reductase M2
SORD sorbitol dehydrogenase
SQLE squalene epoxidase
SUB1 SUB1 homolog (S. cerevisiae)
TAGLN transgelin
TFRC transferrin receptor
TMEM176B transmembrane protein 176B
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9
Funding