BRD-K20755323_-666_MCF7_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

422 genes differentially expressed following the BRD-K20755323_-666_MCF7_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ACADVL acyl-CoA dehydrogenase, very long chain
ACVR1 activin A receptor, type I
ADM adrenomedullin
AHSP alpha hemoglobin stabilizing protein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLVRB biliverdin reductase B
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1ORF106 chromosome 1 open reading frame 106
CALR calreticulin
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAPN2 calpain 2, (m/II) large subunit
CARS cysteinyl-tRNA synthetase
CAST calpastatin
CBS cystathionine-beta-synthase
CCND2 cyclin D2
CCNL1 cyclin L1
CD163 CD163 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD93 CD93 molecule
CDC34 cell division cycle 34
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTNND1 catenin (cadherin-associated protein), delta 1
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
CYTIP cytohesin 1 interacting protein
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DFNA5 deafness, autosomal dominant 5
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNA1 ephrin-A1
EPAS1 endothelial PAS domain protein 1
EPHB4 EPH receptor B4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXT1 exostosin glycosyltransferase 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FKBP11 FK506 binding protein 11, 19 kDa
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FRY furry homolog (Drosophila)
FRZB frizzled-related protein
FTH1 ferritin, heavy polypeptide 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD5 frizzled class receptor 5
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATAD1 GATA zinc finger domain containing 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GPC4 glypican 4
GPR87 G protein-coupled receptor 87
GRB10 growth factor receptor-bound protein 10
GSTA1 glutathione S-transferase alpha 1
GTPBP2 GTP binding protein 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYPC glycophorin C (Gerbich blood group)
HBB hemoglobin, beta
HBD hemoglobin, delta
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JAG1 jagged 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6A lysine (K)-specific demethylase 6A
KLHL24 kelch-like family member 24
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
KRT81 keratin 81, type II
KYNU kynureninase
LAMA3 laminin, alpha 3
LAMP3 lysosomal-associated membrane protein 3
LARP6 La ribonucleoprotein domain family, member 6
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
LXN latexin
LY96 lymphocyte antigen 96
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MPO myeloperoxidase
MPZL2 myelin protein zero-like 2
MSN moesin
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
NVL nuclear VCP-like
OLFM4 olfactomedin 4
ORC1 origin recognition complex, subunit 1
OSER1 oxidative stress responsive serine-rich 1
P3H2 prolyl 3-hydroxylase 2
P4HB prolyl 4-hydroxylase, beta polypeptide
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4B phosphodiesterase 4B, cAMP-specific
PDIA4 protein disulfide isomerase family A, member 4
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIR pirin (iron-binding nuclear protein)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
PPAP2C phosphatidic acid phosphatase type 2C
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
RAB38 RAB38, member RAS oncogene family
RAI14 retinoic acid induced 14
RAP1GAP RAP1 GTPase activating protein
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRBP1 ribosome binding protein 1
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SH3YL1 SH3 and SYLF domain containing 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC12A8 solute carrier family 12, member 8
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
SRGN serglycin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
TACSTD2 tumor-associated calcium signal transducer 2
TALDO1 transaldolase 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TES testin LIM domain protein
TGFA transforming growth factor, alpha
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPP1 tripeptidyl peptidase I
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UPP1 uridine phosphorylase 1
USP3 ubiquitin specific peptidase 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3
ZBED2 zinc finger, BED-type containing 2
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFPM2 zinc finger protein, FOG family member 2
ZNF12 zinc finger protein 12
ZNF274 zinc finger protein 274
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
AKAP7 A kinase (PRKA) anchor protein 7
ANGPT1 angiopoietin 1
APOA2 apolipoprotein A-II
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMT1 acidic residue methyltransferase 1
ASCL1 achaete-scute family bHLH transcription factor 1
ASF1B anti-silencing function 1B histone chaperone
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
AURKA aurora kinase A
AURKB aurora kinase B
BAG3 BCL2-associated athanogene 3
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CHPT1 choline phosphotransferase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COMMD8 COMM domain containing 8
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFCAB11 EF-hand calcium binding domain 11
EFHD1 EF-hand domain family, member D1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELOVL2 ELOVL fatty acid elongase 2
EMP2 epithelial membrane protein 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EVL Enah/Vasp-like
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FAR2 fatty acyl CoA reductase 2
FEN1 flap structure-specific endonuclease 1
FGFR4 fibroblast growth factor receptor 4
FOLR1 folate receptor 1 (adult)
GCH1 GTP cyclohydrolase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHR growth hormone receptor
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPER1 G protein-coupled estrogen receptor 1
GSTM3 glutathione S-transferase mu 3 (brain)
H2AFX H2A histone family, member X
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC10 homeobox C10
HOXC6 homeobox C6
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
ICAM3 intercellular adhesion molecule 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAGE3 L antigen family, member 3
LMNB1 lamin B1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MICB MHC class I polypeptide-related sequence B
MPC2 mitochondrial pyruvate carrier 2
MRPL20 mitochondrial ribosomal protein L20
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPH non-SMC condensin I complex, subunit H
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PCNA proliferating cell nuclear antigen
PEX11A peroxisomal biogenesis factor 11 alpha
PHB prohibitin
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PSRC1 proline/serine-rich coiled-coil 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTTG1 pituitary tumor-transforming 1
QPRT quinolinate phosphoribosyltransferase
RAB5C RAB5C, member RAS oncogene family
RAD54B RAD54 homolog B (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RGS4 regulator of G-protein signaling 4
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SEPW1 selenoprotein W, 1
SFPQ splicing factor proline/glutamine-rich
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
STRA13 stimulated by retinoic acid 13
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFDP1 transcription factor Dp-1
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TMEM50A transmembrane protein 50A
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2N ubiquitin-conjugating enzyme E2N
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGCG UDP-glucose ceramide glucosyltransferase
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein
Funding