BRD-K20755323_-666_NCIH1694_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K20755323_-666_NCIH1694_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
ADGRG1 adhesion G protein-coupled receptor G1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL6A2 collagen, type VI, alpha 2
CREM cAMP responsive element modulator
DDIT4 DNA-damage-inducible transcript 4
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSG3 desmoglein 3
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
FN1 fibronectin 1
GPER1 G protein-coupled estrogen receptor 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
IGFBP5 insulin-like growth factor binding protein 5
IRF4 interferon regulatory factor 4
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KAT6B K(lysine) acetyltransferase 6B
KLK5 kallikrein-related peptidase 5
KRAS Kirsten rat sarcoma viral oncogene homolog
LGALS3 lectin, galactoside-binding, soluble, 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MELK maternal embryonic leucine zipper kinase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
OLFML2A olfactomedin-like 2A
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PLCL2 phospholipase C-like 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS3 protease, serine, 3
PSAP prosaposin
RAD23B RAD23 homolog B (S. cerevisiae)
SCGN secretagogin, EF-hand calcium binding protein
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SFRP1 secreted frizzled-related protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AOC3 amine oxidase, copper containing 3
BIRC5 baculoviral IAP repeat containing 5
C7 complement component 7
CCNA2 cyclin A2
CCNE2 cyclin E2
CEMIP cell migration inducing protein, hyaluronan binding
CHN1 chimerin 1
CKAP4 cytoskeleton-associated protein 4
COL3A1 collagen, type III, alpha 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FGG fibrinogen gamma chain
FLRT2 fibronectin leucine rich transmembrane protein 2
HNMT histamine N-methyltransferase
HOPX HOP homeobox
HOXB2 homeobox B2
HOXB6 homeobox B6
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
LIMCH1 LIM and calponin homology domains 1
NAV2 neuron navigator 2
NOTCH1 notch 1
NUP85 nucleoporin 85kDa
OLFM1 olfactomedin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLIN1 perilipin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB25 RAB25, member RAS oncogene family
SCGB2A1 secretoglobin, family 2A, member 1
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TLR4 toll-like receptor 4
TRIM2 tripartite motif containing 2
TSPAN3 tetraspanin 3
TUBB4B tubulin, beta 4B class IVb
WFDC2 WAP four-disulfide core domain 2
ZCCHC24 zinc finger, CCHC domain containing 24
Funding