BRD-K20755323_-666_NCIH508_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

205 genes differentially expressed following the BRD-K20755323_-666_NCIH508_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CA2 carbonic anhydrase II
CCND2 cyclin D2
COL4A5 collagen, type IV, alpha 5
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CRELD2 cysteine-rich with EGF-like domains 2
DAPK1 death-associated protein kinase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSG3 desmoglein 3
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
ERAP2 endoplasmic reticulum aminopeptidase 2
FBN2 fibrillin 2
FBXO11 F-box protein 11
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FST follistatin
GKN1 gastrokine 1
GLDC glycine dehydrogenase (decarboxylating)
HIST1H2BG histone cluster 1, H2bg
HSPA2 heat shock 70kDa protein 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT16 keratin 16, type I
KRT6B keratin 6B, type II
MEF2C myocyte enhancer factor 2C
MICALL1 MICAL-like 1
MMP9 matrix metallopeptidase 9
MOXD1 monooxygenase, DBH-like 1
MYRF myelin regulatory factor
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PHGDH phosphoglycerate dehydrogenase
PKP1 plakophilin 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PXDN peroxidasin
RAB2A RAB2A, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
TDO2 tryptophan 2,3-dioxygenase
THBS2 thrombospondin 2
TNNT1 troponin T type 1 (skeletal, slow)
TRO trophinin
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
XIST X inactive specific transcript (non-protein coding)
ZNF711 zinc finger protein 711

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
ATG3 autophagy related 3
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BHLHE41 basic helix-loop-helix family, member e41
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
C5ORF15 chromosome 5 open reading frame 15
C8ORF33 chromosome 8 open reading frame 33
CALCA calcitonin-related polypeptide alpha
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNB2 cyclin B2
CCND3 cyclin D3
CD24 CD24 molecule
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRYAB crystallin, alpha B
CSK c-src tyrosine kinase
CYC1 cytochrome c-1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DARS aspartyl-tRNA synthetase
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EBP emopamil binding protein (sterol isomerase)
EDNRB endothelin receptor type B
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5 eukaryotic translation initiation factor 5
EIF5B eukaryotic translation initiation factor 5B
ELOVL5 ELOVL fatty acid elongase 5
EMC2 ER membrane protein complex subunit 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FAM13A family with sequence similarity 13, member A
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPRC5B G protein-coupled receptor, class C, group 5, member B
HBB hemoglobin, beta
HECA headcase homolog (Drosophila)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPH1 heat shock 105kDa/110kDa protein 1
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
KIF2C kinesin family member 2C
KPNB1 karyopherin (importin) beta 1
KRT15 keratin 15, type I
KRT17 keratin 17, type I
L1CAM L1 cell adhesion molecule
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LHFP lipoma HMGIC fusion partner
LRRC16A leucine rich repeat containing 16A
LTF lactotransferrin
LY75 lymphocyte antigen 75
MAB21L2 mab-21-like 2 (C. elegans)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MOAP1 modulator of apoptosis 1
MPZL1 myelin protein zero-like 1
MRPL19 mitochondrial ribosomal protein L19
MRPS30 mitochondrial ribosomal protein S30
MSMO1 methylsterol monooxygenase 1
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
NAMPT nicotinamide phosphoribosyltransferase
NEFH neurofilament, heavy polypeptide
NFIB nuclear factor I/B
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOV nephroblastoma overexpressed
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZD8 PDZ domain containing 8
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
PPARG peroxisome proliferator-activated receptor gamma
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSD3 pleckstrin and Sec7 domain containing 3
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PUF60 poly-U binding splicing factor 60KDa
QDPR quinoid dihydropteridine reductase
RAB40B RAB40B, member RAS oncogene family
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RNMT RNA (guanine-7-) methyltransferase
RPIA ribose 5-phosphate isomerase A
RPL36AL ribosomal protein L36a-like
SC5D sterol-C5-desaturase
SEH1L SEH1-like (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMS spermine synthase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG1 sperm associated antigen 1
SYBU syntabulin (syntaxin-interacting)
TAC1 tachykinin, precursor 1
TARS threonyl-tRNA synthetase
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCERG1 transcription elongation regulator 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
THEM6 thioesterase superfamily member 6
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP4 TIMP metallopeptidase inhibitor 4
TMEM126B transmembrane protein 126B
TRIM2 tripartite motif containing 2
TSPAN8 tetraspanin 8
TTC39A tetratricopeptide repeat domain 39A
TUBB2B tubulin, beta 2B class IIb
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP22 ubiquitin specific peptidase 22
WDR43 WD repeat domain 43
XBP1 X-box binding protein 1
XPO1 exportin 1
Funding