BRD-K20755323_-666_PC3_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

290 genes differentially expressed following the BRD-K20755323_-666_PC3_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALAS1 5'-aminolevulinate synthase 1
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BCL2L2 BCL2-like 2
BLVRB biliverdin reductase B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF132 chromosome 14 open reading frame 132
C1ORF106 chromosome 1 open reading frame 106
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CAST calpastatin
CBS cystathionine-beta-synthase
CCDC92 coiled-coil domain containing 92
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CES2 carboxylesterase 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COLEC12 collectin sub-family member 12
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFS embryonal Fyn-associated substrate
EGFR epidermal growth factor receptor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO2 enolase 2 (gamma, neuronal)
EXT1 exostosin glycosyltransferase 1
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
FZD10 frizzled class receptor 10
GADD45A growth arrest and DNA-damage-inducible, alpha
GALC galactosylceramidase
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
GBE1 glucan (1,4-alpha-), branching enzyme 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
GSTA1 glutathione S-transferase alpha 1
GTPBP2 GTP binding protein 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IRF9 interferon regulatory factor 9
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
LAMP2 lysosomal-associated membrane protein 2
LARP6 La ribonucleoprotein domain family, member 6
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS4 lectin, galactoside-binding, soluble, 4
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
LRP10 low density lipoprotein receptor-related protein 10
MAP1B microtubule-associated protein 1B
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OSBPL10 oxysterol binding protein-like 10
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDGFA platelet-derived growth factor alpha polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHGDH phosphoglycerate dehydrogenase
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAP1GAP RAP1 GTPase activating protein
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
RNF187 ring finger protein 187
RRBP1 ribosome binding protein 1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SELENBP1 selenium binding protein 1
SERINC5 serine incorporator 5
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPAG4 sperm associated antigen 4
SQSTM1 sequestosome 1
SRGN serglycin
STC2 stanniocalcin 2
TCEA1 transcription elongation factor A (SII), 1
TGFA transforming growth factor, alpha
TPP1 tripeptidyl peptidase I
TRAM1 translocation associated membrane protein 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AKAP7 A kinase (PRKA) anchor protein 7
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BCL2A1 BCL2-related protein A1
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BLMH bleomycin hydrolase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CKAP2 cytoskeleton associated protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A2 collagen, type IV, alpha 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUT deoxyuridine triphosphatase
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FH fumarate hydratase
FKBP5 FK506 binding protein 5
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC6 homeobox C6
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MRPS12 mitochondrial ribosomal protein S12
MRPS30 mitochondrial ribosomal protein S30
MYB v-myb avian myeloblastosis viral oncogene homolog
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCAPG non-SMC condensin I complex, subunit G
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PRPF31 pre-mRNA processing factor 31
PRPF4 pre-mRNA processing factor 4
PTMA prothymosin, alpha
PTTG1 pituitary tumor-transforming 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
SEPT11 septin 11
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SORD sorbitol dehydrogenase
SPC25 SPC25, NDC80 kinetochore complex component
SRSF1 serine/arginine-rich splicing factor 1
SRSF7 serine/arginine-rich splicing factor 7
STARD13 StAR-related lipid transfer (START) domain containing 13
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TFAM transcription factor A, mitochondrial
TFDP1 transcription factor Dp-1
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPYL4 TSPY-like 4
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2S ubiquitin-conjugating enzyme E2S
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1
WDR1 WD repeat domain 1
ZBTB18 zinc finger and BTB domain containing 18
ZWILCH zwilch kinetochore protein
Funding