BRD-K20755323_-666_PC3_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K20755323_-666_PC3_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CD163 CD163 molecule
CP ceruloplasmin (ferroxidase)
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FTH1 ferritin, heavy polypeptide 1
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
LIMCH1 LIM and calponin homology domains 1
LMO4 LIM domain only 4
LTF lactotransferrin
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP7 microtubule-associated protein 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NDRG2 NDRG family member 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA3 protein disulfide isomerase family A, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC63 SEC63 homolog (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT9 septin 9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TRIB3 tribbles pseudokinase 3
VCAM1 vascular cell adhesion molecule 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CCND1 cyclin D1
DLC1 DLC1 Rho GTPase activating protein
EFNB2 ephrin-B2
FABP4 fatty acid binding protein 4, adipocyte
FLRT2 fibronectin leucine rich transmembrane protein 2
G0S2 G0/G1 switch 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
LYPD1 LY6/PLAUR domain containing 1
MGLL monoglyceride lipase
PBX3 pre-B-cell leukemia homeobox 3
PLK1 polo-like kinase 1
SMAD3 SMAD family member 3
SNX7 sorting nexin 7
SOX11 SRY (sex determining region Y)-box 11
TLE4 transducin-like enhancer of split 4
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
Funding