BRD-K20755323_-666_THP1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K20755323_-666_THP1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT13 acyl-CoA thioesterase 13
ADIRF adipogenesis regulatory factor
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
C1ORF54 chromosome 1 open reading frame 54
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CERS6 ceramide synthase 6
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKAP4 cytoskeleton-associated protein 4
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COG5 component of oligomeric golgi complex 5
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DST dystonin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM69A family with sequence similarity 69, member A
FOLR1 folate receptor 1 (adult)
GARS glycyl-tRNA synthetase
GNAS GNAS complex locus
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
IFI27 interferon, alpha-inducible protein 27
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KLHDC2 kelch domain containing 2
LAPTM4A lysosomal protein transmembrane 4 alpha
LIMA1 LIM domain and actin binding 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP2K5 mitogen-activated protein kinase kinase 5
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MORC4 MORC family CW-type zinc finger 4
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFRL platelet-derived growth factor receptor-like
PERP PERP, TP53 apoptosis effector
PLS3 plastin 3
PRUNE2 prune homolog 2 (Drosophila)
PTK2 protein tyrosine kinase 2
REEP1 receptor accessory protein 1
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
S100A14 S100 calcium binding protein A14
SCGB1D2 secretoglobin, family 1D, member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX7 sorting nexin 7
STC2 stanniocalcin 2
TES testin LIM domain protein
TPM2 tropomyosin 2 (beta)
TRIB3 tribbles pseudokinase 3
XYLT1 xylosyltransferase I
ZDHHC11 zinc finger, DHHC-type containing 11
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AZU1 azurocidin 1
BIK BCL2-interacting killer (apoptosis-inducing)
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
C9ORF16 chromosome 9 open reading frame 16
CCDC86 coiled-coil domain containing 86
CCNF cyclin F
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBA cytochrome b-245, alpha polypeptide
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FLRT2 fibronectin leucine rich transmembrane protein 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPI glucose-6-phosphate isomerase
GRB14 growth factor receptor-bound protein 14
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
KIAA0907 KIAA0907
KLK2 kallikrein-related peptidase 2
LGALS1 lectin, galactoside-binding, soluble, 1
LPL lipoprotein lipase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MRPS2 mitochondrial ribosomal protein S2
MSMB microseminoprotein, beta-
NKG7 natural killer cell granule protein 7
NKX3-1 NK3 homeobox 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCDH9 protocadherin 9
PLEK pleckstrin
PLK1 polo-like kinase 1
PUF60 poly-U binding splicing factor 60KDa
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
SCAND1 SCAN domain containing 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35F2 solute carrier family 35, member F2
SORD sorbitol dehydrogenase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF1 serine/arginine-rich splicing factor 1
TACSTD2 tumor-associated calcium signal transducer 2
TMEM164 transmembrane protein 164
TNS3 tensin 3
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
UPK1B uroplakin 1B
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding