BRD-K20986251_BL-076_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

55 genes differentially expressed following the BRD-K20986251_BL-076_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTGF connective tissue growth factor
CUX2 cut-like homeobox 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
ELOVL5 ELOVL fatty acid elongase 5
FKBP1B FK506 binding protein 1B, 12.6 kDa
GLRX glutaredoxin (thioltransferase)
IRS2 insulin receptor substrate 2
KIAA1324 KIAA1324
LDLR low density lipoprotein receptor
LTF lactotransferrin
MANSC1 MANSC domain containing 1
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MSMB microseminoprotein, beta-
PPAP2A phosphatidic acid phosphatase type 2A
RAP1GAP RAP1 GTPase activating protein
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SIDT2 SID1 transmembrane family, member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
TGFBI transforming growth factor, beta-induced, 68kDa
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CLU clusterin
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GSTM3 glutathione S-transferase mu 3 (brain)
HOXC10 homeobox C10
HPRT1 hypoxanthine phosphoribosyltransferase 1
KIF2C kinesin family member 2C
LIG1 ligase I, DNA, ATP-dependent
NMU neuromedin U
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
OXCT1 3-oxoacid CoA transferase 1
PCNA proliferating cell nuclear antigen
PLA2G16 phospholipase A2, group XVI
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTTG1 pituitary tumor-transforming 1
RSL1D1 ribosomal L1 domain containing 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB1 tribbles pseudokinase 1
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
Funding