BRD-K21025364_NVP-TAE226_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K21025364_NVP-TAE226_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD24 CD24 molecule
CD9 CD9 molecule
CTSK cathepsin K
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP6 dual specificity phosphatase 6
FCMR Fc fragment of IgM receptor
FLRT2 fibronectin leucine rich transmembrane protein 2
FST follistatin
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
GSTM3 glutathione S-transferase mu 3 (brain)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNMT histamine N-methyltransferase
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
LTB lymphotoxin beta (TNF superfamily, member 3)
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
PLS1 plastin 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PYCARD PYD and CARD domain containing
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A14 S100 calcium binding protein A14
SC5D sterol-C5-desaturase
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD3 SMAD family member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFF1 trefoil factor 1
TOM1L1 target of myb1 (chicken)-like 1
VDAC1 voltage-dependent anion channel 1
YME1L1 YME1-like 1 ATPase

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDOA aldolase A, fructose-bisphosphate
ATF5 activating transcription factor 5
BHLHE41 basic helix-loop-helix family, member e41
CCDC86 coiled-coil domain containing 86
CCL5 chemokine (C-C motif) ligand 5
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHI3L2 chitinase 3-like 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL9A3 collagen, type IX, alpha 3
COTL1 coactosin-like F-actin binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
ELAVL1 ELAV like RNA binding protein 1
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
GBP1 guanylate binding protein 1, interferon-inducible
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRWD1 glutamate-rich WD repeat containing 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAPLN1 hyaluronan and proteoglycan link protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
RGS1 regulator of G-protein signaling 1
S100P S100 calcium binding protein P
SCRG1 stimulator of chondrogenesis 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
TEX10 testis expressed 10
UBE2S ubiquitin-conjugating enzyme E2S
ZBTB20 zinc finger and BTB domain containing 20
Funding