BRD-K21672423_7611062_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K21672423_7611062_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CD52 CD52 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CSRP1 cysteine and glycine-rich protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPAS1 endothelial PAS domain protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM69A family with sequence similarity 69, member A
FKBP11 FK506 binding protein 11, 19 kDa
G6PD glucose-6-phosphate dehydrogenase
GAL galanin/GMAP prepropeptide
GATA2 GATA binding protein 2
GCLM glutamate-cysteine ligase, modifier subunit
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IRS2 insulin receptor substrate 2
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
LPAR6 lysophosphatidic acid receptor 6
MCL1 myeloid cell leukemia 1
MSMO1 methylsterol monooxygenase 1
NFIL3 nuclear factor, interleukin 3 regulated
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
ORC1 origin recognition complex, subunit 1
PHACTR2 phosphatase and actin regulator 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMM2 phosphomannomutase 2
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SHB Src homology 2 domain containing adaptor protein B
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
TBX3 T-box 3
THBD thrombomodulin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WASL Wiskott-Aldrich syndrome-like
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALCAM activated leukocyte cell adhesion molecule
AP2M1 adaptor-related protein complex 2, mu 1 subunit
B3GNT1
BST2 bone marrow stromal cell antigen 2
CALB1 calbindin 1, 28kDa
CCL19 chemokine (C-C motif) ligand 19
CCNG1 cyclin G1
CD59 CD59 molecule, complement regulatory protein
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CHL1 cell adhesion molecule L1-like
COL13A1 collagen, type XIII, alpha 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYBA cytochrome b-245, alpha polypeptide
DCN decorin
DDHD2 DDHD domain containing 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
ECI2 enoyl-CoA delta isomerase 2
EMP3 epithelial membrane protein 3
FLRT2 fibronectin leucine rich transmembrane protein 2
GAS1 growth arrest-specific 1
GOLGA8A golgin A8 family, member A
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HOXA10 homeobox A10
HOXC6 homeobox C6
IL27RA interleukin 27 receptor, alpha
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP5 lysosomal-associated membrane protein family, member 5
LIG1 ligase I, DNA, ATP-dependent
LOXL1 lysyl oxidase-like 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MLANA melan-A
MTDH metadherin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2 notch 2
NTS neurotensin
NUP210 nucleoporin 210kDa
PARP4 poly (ADP-ribose) polymerase family, member 4
PEBP1 phosphatidylethanolamine binding protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRR7 proline rich 7 (synaptic)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RBP1 retinol binding protein 1, cellular
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLCO1B3 solute carrier organic anion transporter family, member 1B3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Funding