BRD-K21680192_mitoxantrone_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K21680192_mitoxantrone_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
APOC1 apolipoprotein C-I
ARL4C ADP-ribosylation factor-like 4C
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX1 brain expressed, X-linked 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CELF2 CUGBP, Elav-like family member 2
CENPU centromere protein U
CLGN calmegin
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CST3 cystatin C
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DCK deoxycytidine kinase
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
DSG3 desmoglein 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEM GTP binding protein overexpressed in skeletal muscle
GINS1 GINS complex subunit 1 (Psf1 homolog)
HBB hemoglobin, beta
HIST1H2BK histone cluster 1, H2bk
ICMT isoprenylcysteine carboxyl methyltransferase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL2RG interleukin 2 receptor, gamma
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIG1 ligase I, DNA, ATP-dependent
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MTCL1 microtubule crosslinking factor 1
MX1 MX dynamin-like GTPase 1
NEFL neurofilament, light polypeptide
NNMT nicotinamide N-methyltransferase
OPN3 opsin 3
PALLD palladin, cytoskeletal associated protein
PEA15 phosphoprotein enriched in astrocytes 15
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXDC1 PX domain containing 1
RAD51C RAD51 paralog C
RCAN1 regulator of calcineurin 1
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
RRM2 ribonucleotide reductase M2
SAMD4A sterile alpha motif domain containing 4A
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SPRR1B small proline-rich protein 1B
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFRC transferrin receptor
TRIM2 tripartite motif containing 2
TSPAN3 tetraspanin 3
USP1 ubiquitin specific peptidase 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZWINT ZW10 interacting kinetochore protein

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALCAM activated leukocyte cell adhesion molecule
ARHGAP6 Rho GTPase activating protein 6
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
CA12 carbonic anhydrase XII
CCNB2 cyclin B2
CDC20 cell division cycle 20
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMBT1 deleted in malignant brain tumors 1
DTX4 deltex 4, E3 ubiquitin ligase
ELF5 E74-like factor 5 (ets domain transcription factor)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FRZB frizzled-related protein
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFT57 intraflagellar transport 57
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KYNU kynureninase
LGALS1 lectin, galactoside-binding, soluble, 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LY75 lymphocyte antigen 75
MALL mal, T-cell differentiation protein-like
MMP3 matrix metallopeptidase 3
MTDH metadherin
MVP major vault protein
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PFN2 profilin 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
PLS1 plastin 1
PRRC2C proline-rich coiled-coil 2C
PSCA prostate stem cell antigen
PSRC1 proline/serine-rich coiled-coil 1
RPS11 ribosomal protein S11
S100P S100 calcium binding protein P
SATB2 SATB homeobox 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIRT3 sirtuin 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
THBS1 thrombospondin 1
TKT transketolase
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPR translocated promoter region, nuclear basket protein
TREM1 triggering receptor expressed on myeloid cells 1
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP8 vesicle-associated membrane protein 8
Funding