BRD-K21680192_mitoxantrone_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

264 genes differentially expressed following the BRD-K21680192_mitoxantrone_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACO2 aconitase 2, mitochondrial
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
BEX4 brain expressed, X-linked 4
BLCAP bladder cancer associated protein
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CCND2 cyclin D2
CD9 CD9 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CLCA2 chloride channel accessory 2
COL4A5 collagen, type IV, alpha 5
COL7A1 collagen, type VII, alpha 1
CSTA cystatin A (stefin A)
CTSC cathepsin C
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DDR1 discoidin domain receptor tyrosine kinase 1
DENND2D DENN/MADD domain containing 2D
DERA deoxyribose-phosphate aldolase (putative)
DFNA5 deafness, autosomal dominant 5
DGKA diacylglycerol kinase, alpha 80kDa
DHRS7 dehydrogenase/reductase (SDR family) member 7
DLK1 delta-like 1 homolog (Drosophila)
DSG3 desmoglein 3
DSP desmoplakin
DST dystonin
DUSP14 dual specificity phosphatase 14
EGFR epidermal growth factor receptor
FAM134B family with sequence similarity 134, member B
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FCGBP Fc fragment of IgG binding protein
FDXR ferredoxin reductase
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45A growth arrest and DNA-damage-inducible, alpha
GALC galactosylceramidase
GALE UDP-galactose-4-epimerase
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPC1 glypican 1
GPR87 G protein-coupled receptor 87
GSAP gamma-secretase activating protein
GSN gelsolin
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HSPA4L heat shock 70kDa protein 4-like
HSPB8 heat shock 22kDa protein 8
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
INPP1 inositol polyphosphate-1-phosphatase
IRF9 interferon regulatory factor 9
ITGB4 integrin, beta 4
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF5 Kruppel-like factor 5 (intestinal)
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMK2 LIM domain kinase 2
LRRN3 leucine rich repeat neuronal 3
LY6D lymphocyte antigen 6 complex, locus D
LYPD3 LY6/PLAUR domain containing 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MICALL1 MICAL-like 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
MYO6 myosin VI
NDRG2 NDRG family member 2
NPDC1 neural proliferation, differentiation and control, 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
PDLIM1 PDZ and LIM domain 1
PERP PERP, TP53 apoptosis effector
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLAU plasminogen activator, urokinase
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPL periplakin
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTN pleiotrophin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB38 RAB38, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RPS27L ribosomal protein S27-like
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RUNX3 runt-related transcription factor 3
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
SPRR1B small proline-rich protein 1B
STAT1 signal transducer and activator of transcription 1, 91kDa
SYNM synemin, intermediate filament protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TGFA transforming growth factor, alpha
THBD thrombomodulin
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM259 transmembrane protein 259
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TOX3 TOX high mobility group box family member 3
TP63 tumor protein p63
TRIM22 tripartite motif containing 22
TXNIP thioredoxin interacting protein
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
XPC xeroderma pigmentosum, complementation group C
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BGN biglycan
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C4BPA complement component 4 binding protein, alpha
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDKN3 cyclin-dependent kinase inhibitor 3
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A2 collagen, type I, alpha 2
CRISP3 cysteine-rich secretory protein 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDAH2 dimethylarginine dimethylaminohydrolase 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FAM64A family with sequence similarity 64, member A
GAL galanin/GMAP prepropeptide
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPC3 glypican 3
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
HOXA10 homeobox A10
HOXC6 homeobox C6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
INSIG1 insulin induced gene 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMP5 lysosomal-associated membrane protein family, member 5
LDB2 LIM domain binding 2
LDLR low density lipoprotein receptor
LEPR leptin receptor
LOC100505650 uncharacterized LOC100505650
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MSH6 mutS homolog 6
MSLN mesothelin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NNMT nicotinamide N-methyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PECAM1 platelet/endothelial cell adhesion molecule 1
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRC1 protein regulator of cytokinesis 1
PRKD3 protein kinase D3
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
PTMA prothymosin, alpha
PTTG1 pituitary tumor-transforming 1
QPRT quinolinate phosphoribosyltransferase
SATB1 SATB homeobox 1
SEPHS1 selenophosphate synthetase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC35F2 solute carrier family 35, member F2
SPC25 SPC25, NDC80 kinetochore complex component
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TACC3 transforming, acidic coiled-coil containing protein 3
TBL1X transducin (beta)-like 1X-linked
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCF4 transcription factor 4
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNS1 tensin 1
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VAT1 vesicle amine transport 1
VCAN versican
ZHX2 zinc fingers and homeoboxes 2
ZNF423 zinc finger protein 423
Funding