BRD-K21680192_mitoxantrone_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

406 genes differentially expressed following the BRD-K21680192_mitoxantrone_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ACP5 acid phosphatase 5, tartrate resistant
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AIF1 allograft inflammatory factor 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
APLP2 amyloid beta (A4) precursor-like protein 2
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ARHGAP25 Rho GTPase activating protein 25
ARHGAP32 Rho GTPase activating protein 32
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPH aspartate beta-hydroxylase
ASPN asporin
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAM basal cell adhesion molecule (Lutheran blood group)
BCHE butyrylcholinesterase
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLNK B-cell linker
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCL8 chemokine (C-C motif) ligand 8
CCRL2 chemokine (C-C motif) receptor-like 2
CD302 CD302 molecule
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFD complement factor D (adipsin)
CFH complement factor H
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC11A C-type lectin domain family 11, member A
CLEC2B C-type lectin domain family 2, member B
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
COL21A1 collagen, type XXI, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CPM carboxypeptidase M
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CTSK cathepsin K
CTSO cathepsin O
CTSS cathepsin S
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYB561 cytochrome b561
DAZAP2 DAZ associated protein 2
DCN decorin
DDR2 discoidin domain receptor tyrosine kinase 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPT dermatopontin
EFHC2 EF-hand domain (C-terminal) containing 2
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXPH5 exophilin 5
F11R F11 receptor
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGFR3 fibroblast growth factor receptor 3
FLT1 fms-related tyrosine kinase 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FPR3 formyl peptide receptor 3
FST follistatin
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPC4 glypican 4
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GUSBP3 glucuronidase, beta pseudogene 3
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN5 high mobility group nucleosome binding domain 5
HP haptoglobin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTRA1 HtrA serine peptidase 1
IDO1 indoleamine 2,3-dioxygenase 1
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGSF6 immunoglobulin superfamily, member 6
IL13RA2 interleukin 13 receptor, alpha 2
IL1RN interleukin 1 receptor antagonist
IRF6 interferon regulatory factor 6
ISYNA1 inositol-3-phosphate synthase 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITM2A integral membrane protein 2A
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KYNU kynureninase
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMA4 laminin, alpha 4
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LGALS3 lectin, galactoside-binding, soluble, 3
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC15 leucine rich repeat containing 15
LTA4H leukotriene A4 hydrolase
LTBP1 latent transforming growth factor beta binding protein 1
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MANSC1 MANSC domain containing 1
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MMP9 matrix metallopeptidase 9
MSR1 macrophage scavenger receptor 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYO6 myosin VI
NCF2 neutrophil cytosolic factor 2
NEBL nebulette
NGRN neugrin, neurite outgrowth associated
NMU neuromedin U
NPDC1 neural proliferation, differentiation and control, 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRP1 neuropilin 1
NTS neurotensin
PARM1 prostate androgen-regulated mucin-like protein 1
PCDH17 protocadherin 17
PCOLCE procollagen C-endopeptidase enhancer
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS21 protease, serine, 21 (testisin)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RCAN2 regulator of calcineurin 2
REEP5 receptor accessory protein 5
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL31 ribosomal protein L31
RSAD2 radical S-adenosyl methionine domain containing 2
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SH3BGR SH3 domain binding glutamate-rich protein
SH3BGRL SH3 domain binding glutamate-rich protein like
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX10 sorting nexin 10
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSPN sarcospan
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TCF4 transcription factor 4
TF transferrin
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THBD thrombomodulin
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM231 transmembrane protein 231
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TMEM50B transmembrane protein 50B
TNNT1 troponin T type 1 (skeletal, slow)
TOX thymocyte selection-associated high mobility group box
TP53TG1 TP53 target 1 (non-protein coding)
TPP1 tripeptidyl peptidase I
TRBC1 T cell receptor beta constant 1
TREM2 triggering receptor expressed on myeloid cells 2
TRPS1 trichorhinophalangeal syndrome I
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
UBE2B ubiquitin-conjugating enzyme E2B
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VWA5A von Willebrand factor A domain containing 5A
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF264 zinc finger protein 264
ZNF467 zinc finger protein 467

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACLY ATP citrate lyase
AHNAK AHNAK nucleoprotein
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATG3 autophagy related 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BHLHE40 basic helix-loop-helix family, member e40
BLVRA biliverdin reductase A
CBX1 chromobox homolog 1
CCNA2 cyclin A2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CLTA clathrin, light chain A
COA3 cytochrome c oxidase assembly factor 3
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRYAB crystallin, alpha B
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPP4 dipeptidyl-peptidase 4
DPYSL2 dihydropyrimidinase-like 2
DUSP5 dual specificity phosphatase 5
EIF4A3 eukaryotic translation initiation factor 4A3
FBL fibrillarin
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GALE UDP-galactose-4-epimerase
GLOD4 glyoxalase domain containing 4
GNAS GNAS complex locus
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KEAP1 kelch-like ECH-associated protein 1
KIAA0125 KIAA0125
KIF1BP KIF1 binding protein
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNB1 karyopherin (importin) beta 1
KRT10 keratin 10, type I
KRT7 keratin 7, type II
LASP1 LIM and SH3 protein 1
LDLR low density lipoprotein receptor
LPIN1 lipin 1
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MRPL12 mitochondrial ribosomal protein L12
MYBPC1 myosin binding protein C, slow type
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NPY1R neuropeptide Y receptor Y1
NUP62 nucleoporin 62kDa
NXN nucleoredoxin
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PUF60 poly-U binding splicing factor 60KDa
RAB14 RAB14, member RAS oncogene family
RBPMS RNA binding protein with multiple splicing
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A10 S100 calcium binding protein A10
SACS sacsin molecular chaperone
SCAND1 SCAN domain containing 1
SEPT11 septin 11
SERBP1 SERPINE1 mRNA binding protein 1
SETD5 SET domain containing 5
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TJP2 tight junction protein 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNIP1 TNFAIP3 interacting protein 1
TPX2 TPX2, microtubule-associated
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBE2I ubiquitin-conjugating enzyme E2I
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WDR6 WD repeat domain 6
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding