BRD-K21680192_mitoxantrone_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

388 genes differentially expressed following the BRD-K21680192_mitoxantrone_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD2 abhydrolase domain containing 2
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
AFF1 AF4/FMR2 family, member 1
AKAP8L A kinase (PRKA) anchor protein 8-like
AKIRIN1 akirin 1
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
BLCAP bladder cancer associated protein
BRD2 bromodomain containing 2
BTBD1 BTB (POZ) domain containing 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C3ORF52 chromosome 3 open reading frame 52
C9ORF3 chromosome 9 open reading frame 3
CAPN2 calpain 2, (m/II) large subunit
CCND2 cyclin D2
CD47 CD47 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHMP1B charged multivesicular body protein 1B
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
CLGN calmegin
CST3 cystatin C
CTSB cathepsin B
CTSS cathepsin S
CTSZ cathepsin Z
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDR1 discoidin domain receptor tyrosine kinase 1
DOCK9 dedicator of cytokinesis 9
DSG3 desmoglein 3
DST dystonin
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGBP Fc fragment of IgG binding protein
FHOD3 formin homology 2 domain containing 3
FNDC3B fibronectin type III domain containing 3B
FUCA1 fucosidase, alpha-L- 1, tissue
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GPR87 G protein-coupled receptor 87
GRN granulin
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HDGFRP3 hepatoma-derived growth factor, related protein 3
HES1 hes family bHLH transcription factor 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL6R interleukin 6 receptor
INPP1 inositol polyphosphate-1-phosphatase
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
ISCU iron-sulfur cluster assembly enzyme
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JAG1 jagged 1
JUNB jun B proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LIMCH1 LIM and calponin homology domains 1
LPXN leupaxin
LRP10 low density lipoprotein receptor-related protein 10
LTBP3 latent transforming growth factor beta binding protein 3
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP7 microtubule-associated protein 7
MAP7D1 MAP7 domain containing 1
MCL1 myeloid cell leukemia 1
MEIS1 Meis homeobox 1
MFSD1 major facilitator superfamily domain containing 1
MICALL1 MICAL-like 1
MIR22HG MIR22 host gene
MMP12 matrix metallopeptidase 12
NCF2 neutrophil cytosolic factor 2
NEFL neurofilament, light polypeptide
NMRK1 nicotinamide riboside kinase 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PERP PERP, TP53 apoptosis effector
PHF1 PHD finger protein 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLCB4 phospholipase C, beta 4
PLEK2 pleckstrin 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PNMAL1 paraneoplastic Ma antigen family-like 1
POPDC3 popeye domain containing 3
PSAP prosaposin
PTHLH parathyroid hormone-like hormone
QPCT glutaminyl-peptide cyclotransferase
RAB4A RAB4A, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RPL37A ribosomal protein L37a
RPS27L ribosomal protein S27-like
RRAGD Ras-related GTP binding D
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
STOM stomatin
TBX3 T-box 3
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
THBD thrombomodulin
TICAM1 toll-like receptor adaptor molecule 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM30B transmembrane protein 30B
TOB1 transducer of ERBB2, 1
TP53I3 tumor protein p53 inducible protein 3
TP63 tumor protein p63
TRIM29 tripartite motif containing 29
TSKU tsukushi, small leucine rich proteoglycan
TWF2 twinfilin actin binding protein 2
VNN1 vanin 1
WDR1 WD repeat domain 1
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZBTB43 zinc finger and BTB domain containing 43
ZC3H12A zinc finger CCCH-type containing 12A
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACSL1 acyl-CoA synthetase long-chain family member 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
ALPL alkaline phosphatase, liver/bone/kidney
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASPN asporin
ASS1 argininosuccinate synthase 1
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C6ORF62 chromosome 6 open reading frame 62
CALU calumenin
CBS cystathionine-beta-synthase
CBX3 chromobox homolog 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CD36 CD36 molecule (thrombospondin receptor)
CD99 CD99 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CLIC4 chloride intracellular channel 4
CNN3 calponin 3, acidic
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
CRABP2 cellular retinoic acid binding protein 2
DCK deoxycytidine kinase
DCN decorin
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETFB electron-transfer-flavoprotein, beta polypeptide
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM35A family with sequence similarity 35, member A
FAM64A family with sequence similarity 64, member A
FASN fatty acid synthase
FBXO21 F-box protein 21
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
FGFR2 fibroblast growth factor receptor 2
FOXM1 forkhead box M1
FXYD2 FXYD domain containing ion transport regulator 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLUD1 glutamate dehydrogenase 1
GTF3A general transcription factor IIIA
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAT1 histone acetyltransferase 1
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM2 interferon induced transmembrane protein 2
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LMNB1 lamin B1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
METRN meteorin, glial cell differentiation regulator
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MRPL12 mitochondrial ribosomal protein L12
MSMO1 methylsterol monooxygenase 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUSAP1 nucleolar and spindle associated protein 1
NVL nuclear VCP-like
OLFML3 olfactomedin-like 3
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLD2 polymerase (DNA directed), delta 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RBPMS RNA binding protein with multiple splicing
RCC1 regulator of chromosome condensation 1
RFC3 replication factor C (activator 1) 3, 38kDa
RGS1 regulator of G-protein signaling 1
RNASE4 ribonuclease, RNase A family, 4
RRM2 ribonucleotide reductase M2
SAP30 Sin3A-associated protein, 30kDa
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPHS1 selenophosphate synthetase 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A4RG SLC2A4 regulator
SNX10 sorting nexin 10
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TK1 thymidine kinase 1, soluble
TKT transketolase
TM9SF3 transmembrane 9 superfamily member 3
TMEM123 transmembrane protein 123
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIB3 tribbles pseudokinase 3
TRIP13 thyroid hormone receptor interactor 13
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
VCAM1 vascular cell adhesion molecule 1
VCAN versican
XBP1 X-box binding protein 1
XPOT exportin, tRNA
XYLT1 xylosyltransferase I
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein
Funding