| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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152 genes differentially expressed following the BRD-K21680192_mitoxantrone_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ACTA2 | actin, alpha 2, smooth muscle, aorta |
| ADAM10 | ADAM metallopeptidase domain 10 |
| AGR2 | anterior gradient 2 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) |
| BZW2 | basic leucine zipper and W2 domains 2 |
| C14ORF132 | chromosome 14 open reading frame 132 |
| C4ORF27 | chromosome 4 open reading frame 27 |
| CADM1 | cell adhesion molecule 1 |
| CECR1 | cat eye syndrome chromosome region, candidate 1 |
| CETN3 | centrin, EF-hand protein, 3 |
| CLDN10 | claudin 10 |
| CRYAB | crystallin, alpha B |
| CSRP2 | cysteine and glycine-rich protein 2 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 |
| CYBA | cytochrome b-245, alpha polypeptide |
| DEFB1 | defensin, beta 1 |
| DEPTOR | DEP domain containing MTOR-interacting protein |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 |
| EGR1 | early growth response 1 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 |
| GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 |
| GPX3 | glutathione peroxidase 3 |
| GSTT1 | glutathione S-transferase theta 1 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 |
| HBB | hemoglobin, beta |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 |
| HLTF | helicase-like transcription factor |
| HSPB8 | heat shock 22kDa protein 8 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
| IFI6 | interferon, alpha-inducible protein 6 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa |
| IL1B | interleukin 1, beta |
| ITM2A | integral membrane protein 2A |
| ITM2C | integral membrane protein 2C |
| KIF5C | kinesin family member 5C |
| LAGE3 | L antigen family, member 3 |
| LCN2 | lipocalin 2 |
| LEF1 | lymphoid enhancer-binding factor 1 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 |
| MDK | midkine (neurite growth-promoting factor 2) |
| MXRA5 | matrix-remodelling associated 5 |
| NID2 | nidogen 2 (osteonidogen) |
| NOTCH3 | notch 3 |
| NSG1 | neuron specific gene family member 1 |
| PCOLCE | procollagen C-endopeptidase enhancer |
| PDIA4 | protein disulfide isomerase family A, member 4 |
| PSAT1 | phosphoserine aminotransferase 1 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| QPRT | quinolinate phosphoribosyltransferase |
| RBP1 | retinol binding protein 1, cellular |
| SCG2 | secretogranin II |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
| SPON1 | spondin 1, extracellular matrix protein |
| SST | somatostatin |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 |
| TBX2 | T-box 2 |
| TFPI2 | tissue factor pathway inhibitor 2 |
| TMEM30B | transmembrane protein 30B |
| TMEM47 | transmembrane protein 47 |
| TMOD1 | tropomodulin 1 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 |
| TSC22D3 | TSC22 domain family, member 3 |
| TSPAN13 | tetraspanin 13 |
| TSPAN8 | tetraspanin 8 |
| Symbol | Name |
|---|---|
| ALB | albumin |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 |
| AXL | AXL receptor tyrosine kinase |
| BMP2 | bone morphogenetic protein 2 |
| CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
| CCL5 | chemokine (C-C motif) ligand 5 |
| CCNE2 | cyclin E2 |
| CCNF | cyclin F |
| CDCA4 | cell division cycle associated 4 |
| COL4A5 | collagen, type IV, alpha 5 |
| DDIT4 | DNA-damage-inducible transcript 4 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP5 | dual specificity phosphatase 5 |
| DUSP6 | dual specificity phosphatase 6 |
| EIF5 | eukaryotic translation initiation factor 5 |
| FASTKD5 | FAST kinase domains 5 |
| FEM1C | fem-1 homolog c (C. elegans) |
| FHL2 | four and a half LIM domains 2 |
| FOSL1 | FOS-like antigen 1 |
| FOSL2 | FOS-like antigen 2 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
| GZMK | granzyme K (granzyme 3; tryptase II) |
| HBEGF | heparin-binding EGF-like growth factor |
| HMGA2 | high mobility group AT-hook 2 |
| HMOX1 | heme oxygenase 1 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L |
| ICAM1 | intercellular adhesion molecule 1 |
| IER3 | immediate early response 3 |
| IER5 | immediate early response 5 |
| IL4R | interleukin 4 receptor |
| JMJD6 | jumonji domain containing 6 |
| KRT6B | keratin 6B, type II |
| LDLR | low density lipoprotein receptor |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MCL1 | myeloid cell leukemia 1 |
| MED17 | mediator complex subunit 17 |
| MTF2 | metal response element binding transcription factor 2 |
| MTSS1 | metastasis suppressor 1 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog |
| NAV2 | neuron navigator 2 |
| NFIL3 | nuclear factor, interleukin 3 regulated |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| NOTCH2 | notch 2 |
| NRIP1 | nuclear receptor interacting protein 1 |
| PDGFA | platelet-derived growth factor alpha polypeptide |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
| PLK2 | polo-like kinase 2 |
| PTPRO | protein tyrosine phosphatase, receptor type, O |
| PTX3 | pentraxin 3, long |
| RAP2B | RAP2B, member of RAS oncogene family |
| RBM15 | RNA binding motif protein 15 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B |
| RGS2 | regulator of G-protein signaling 2 |
| RND3 | Rho family GTPase 3 |
| RPL37A | ribosomal protein L37a |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 |
| SDC4 | syndecan 4 |
| SLC29A1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 |
| SMAD3 | SMAD family member 3 |
| SOCS1 | suppressor of cytokine signaling 1 |
| SPRY2 | sprouty homolog 2 (Drosophila) |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa |
| THBS1 | thrombospondin 1 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase |
| TLR4 | toll-like receptor 4 |
| TM4SF1 | transmembrane 4 L six family member 1 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 |
| TSC22D2 | TSC22 domain family, member 2 |
| UGCG | UDP-glucose ceramide glucosyltransferase |
| VCL | vinculin |
| VEZF1 | vascular endothelial zinc finger 1 |
| WEE1 | WEE1 G2 checkpoint kinase |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 |
| ZCCHC2 | zinc finger, CCHC domain containing 2 |
| ZFP36 | ZFP36 ring finger protein |
| ZNF281 | zinc finger protein 281 |
