| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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160 genes differentially expressed following the BRD-K21680192_mitoxantrone_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| AKR1C3 | aldo-keto reductase family 1, member C3 |
| ATF5 | activating transcription factor 5 |
| BIRC3 | baculoviral IAP repeat containing 3 |
| CCL20 | chemokine (C-C motif) ligand 20 |
| CCL5 | chemokine (C-C motif) ligand 5 |
| CCNE2 | cyclin E2 |
| CDC25A | cell division cycle 25A |
| CDC45 | cell division cycle 45 |
| CDC6 | cell division cycle 6 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| CXCL10 | chemokine (C-X-C motif) ligand 10 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 |
| CYB5R1 | cytochrome b5 reductase 1 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DUSP5 | dual specificity phosphatase 5 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 |
| FBLN1 | fibulin 1 |
| FEN1 | flap structure-specific endonuclease 1 |
| FGFR3 | fibroblast growth factor receptor 3 |
| FHL1 | four and a half LIM domains 1 |
| GDF15 | growth differentiation factor 15 |
| GLRX | glutaredoxin (thioltransferase) |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
| HDAC9 | histone deacetylase 9 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) |
| IDO1 | indoleamine 2,3-dioxygenase 1 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 |
| IGKC | immunoglobulin kappa constant |
| IGKV4-1 | immunoglobulin kappa variable 4-1 |
| ITM2C | integral membrane protein 2C |
| KIF5C | kinesin family member 5C |
| KLF4 | Kruppel-like factor 4 (gut) |
| KRT19 | keratin 19, type I |
| LAMA3 | laminin, alpha 3 |
| LAMP3 | lysosomal-associated membrane protein 3 |
| LEF1 | lymphoid enhancer-binding factor 1 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MCM4 | minichromosome maintenance complex component 4 |
| MICB | MHC class I polypeptide-related sequence B |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 |
| MTCL1 | microtubule crosslinking factor 1 |
| MTSS1 | metastasis suppressor 1 |
| NEB | nebulin |
| NEFL | neurofilament, light polypeptide |
| PERP | PERP, TP53 apoptosis effector |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) |
| RCAN1 | regulator of calcineurin 1 |
| RFC2 | replication factor C (activator 1) 2, 40kDa |
| RHOB | ras homolog family member B |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
| SFN | stratifin |
| SGK1 | serum/glucocorticoid regulated kinase 1 |
| SLC25A4 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 |
| SNAP25 | synaptosomal-associated protein, 25kDa |
| SOD2 | superoxide dismutase 2, mitochondrial |
| TATDN2 | TatD DNase domain containing 2 |
| TGFA | transforming growth factor, alpha |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 |
| TRAPPC3 | trafficking protein particle complex 3 |
| TRIB2 | tribbles pseudokinase 2 |
| TSPAN7 | tetraspanin 7 |
| VNN1 | vanin 1 |
| XIST | X inactive specific transcript (non-protein coding) |
| ZWINT | ZW10 interacting kinetochore protein |
| Symbol | Name |
|---|---|
| ACSL1 | acyl-CoA synthetase long-chain family member 1 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric |
| ADK | adenosine kinase |
| AKAP13 | A kinase (PRKA) anchor protein 13 |
| ANK2 | ankyrin 2, neuronal |
| ANXA3 | annexin A3 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) |
| AUTS2 | autism susceptibility candidate 2 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic |
| CD163 | CD163 molecule |
| CD44 | CD44 molecule (Indian blood group) |
| CENPA | centromere protein A |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) |
| CHI3L2 | chitinase 3-like 2 |
| CHRDL1 | chordin-like 1 |
| CKAP4 | cytoskeleton-associated protein 4 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| DDIT4 | DNA-damage-inducible transcript 4 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
| DLK1 | delta-like 1 homolog (Drosophila) |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 |
| EPHA3 | EPH receptor A3 |
| FAM171A1 | family with sequence similarity 171, member A1 |
| FXYD5 | FXYD domain containing ion transport regulator 5 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi |
| GAS1 | growth arrest-specific 1 |
| GLS | glutaminase |
| GSTO1 | glutathione S-transferase omega 1 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 |
| HMOX1 | heme oxygenase 1 |
| HOXA5 | homeobox A5 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') |
| IRS1 | insulin receptor substrate 1 |
| JAM3 | junctional adhesion molecule 3 |
| KDM5D | lysine (K)-specific demethylase 5D |
| KIAA1033 | KIAA1033 |
| KIF20A | kinesin family member 20A |
| LAPTM5 | lysosomal protein transmembrane 5 |
| LIMCH1 | LIM and calponin homology domains 1 |
| LMO4 | LIM domain only 4 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B |
| MEIS2 | Meis homeobox 2 |
| MINA | MYC induced nuclear antigen |
| NFIB | nuclear factor I/B |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 |
| NRP1 | neuropilin 1 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit |
| PAPD7 | PAP associated domain containing 7 |
| PCDH9 | protocadherin 9 |
| PEG3 | paternally expressed 3 |
| PLK1 | polo-like kinase 1 |
| PLS3 | plastin 3 |
| PODXL | podocalyxin-like |
| PPAP2B | phosphatidic acid phosphatase type 2B |
| PSRC1 | proline/serine-rich coiled-coil 1 |
| PTN | pleiotrophin |
| PTPRK | protein tyrosine phosphatase, receptor type, K |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 |
| PXDN | peroxidasin |
| RPS11 | ribosomal protein S11 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 |
| RUFY3 | RUN and FYVE domain containing 3 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) |
| SDC2 | syndecan 2 |
| SEC63 | SEC63 homolog (S. cerevisiae) |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 |
| SLIT2 | slit homolog 2 (Drosophila) |
| SOBP | sine oculis binding protein homolog (Drosophila) |
| SPP1 | secreted phosphoprotein 1 |
| SQLE | squalene epoxidase |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) |
| TCF4 | transcription factor 4 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) |
| TFF1 | trefoil factor 1 |
| TGFB3 | transforming growth factor, beta 3 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 |
| TMEM45A | transmembrane protein 45A |
| TNC | tenascin C |
| WWTR1 | WW domain containing transcription regulator 1 |
| ZIC1 | Zic family member 1 |
