BRD-K21680192_mitoxantrone_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-K21680192_mitoxantrone_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ADK adenosine kinase
ADRB2 adrenoceptor beta 2, surface
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANXA10 annexin A10
AQP3 aquaporin 3 (Gill blood group)
BCAM basal cell adhesion molecule (Lutheran blood group)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BLNK B-cell linker
CADM1 cell adhesion molecule 1
CAPG capping protein (actin filament), gelsolin-like
CAV2 caveolin 2
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLDN18 claudin 18
CNPY3 canopy FGF signaling regulator 3
COG2 component of oligomeric golgi complex 2
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CPVL carboxypeptidase, vitellogenic-like
CRLF1 cytokine receptor-like factor 1
CSTA cystatin A (stefin A)
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
CYBB cytochrome b-245, beta polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
ESRRG estrogen-related receptor gamma
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FZD6 frizzled class receptor 6
GPER1 G protein-coupled estrogen receptor 1
GPM6A glycoprotein M6A
HCAR3 hydroxycarboxylic acid receptor 3
HOPX HOP homeobox
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IGFBP5 insulin-like growth factor binding protein 5
IL18 interleukin 18
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KRT7 keratin 7, type II
LAMP3 lysosomal-associated membrane protein 3
LEPR leptin receptor
LIMCH1 LIM and calponin homology domains 1
LPL lipoprotein lipase
MAOA monoamine oxidase A
MYL1 myosin, light chain 1, alkali; skeletal, fast
NEBL nebulette
NMU neuromedin U
NRCAM neuronal cell adhesion molecule
NREP neuronal regeneration related protein
NTS neurotensin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLS3 plastin 3
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SCARB2 scavenger receptor class B, member 2
SCEL sciellin
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SEPW1 selenoprotein W, 1
SFTPB surfactant protein B
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TBX2 T-box 2
TMEM45A transmembrane protein 45A
TNNC1 troponin C type 1 (slow)
TNNC2 troponin C type 2 (fast)
TNNI2 troponin I type 2 (skeletal, fast)
TPGS2 tubulin polyglutamylase complex subunit 2
TTN titin
VAMP7 vesicle-associated membrane protein 7

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOB aldolase B, fructose-bisphosphate
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CTGF connective tissue growth factor
CTSK cathepsin K
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFNB2 ephrin-B2
EGR2 early growth response 2
EGR3 early growth response 3
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXOSC4 exosome component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASTKD5 FAST kinase domains 5
FEM1C fem-1 homolog c (C. elegans)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HJURP Holliday junction recognition protein
HOXA5 homeobox A5
HSPA8 heat shock 70kDa protein 8
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT18 keratin 18, type I
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MGP matrix Gla protein
MKNK2 MAP kinase interacting serine/threonine kinase 2
MRPS30 mitochondrial ribosomal protein S30
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP56 NOP56 ribonucleoprotein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRN1 neuritin 1
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK2 polo-like kinase 2
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTX3 pentraxin 3, long
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS1 regulator of G-protein signaling 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RPL38 ribosomal protein L38
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
SATB2 SATB homeobox 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SETMAR SET domain and mariner transposase fusion gene
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SSH1 slingshot protein phosphatase 1
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM70 transmembrane protein 70
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB2 transducer of ERBB2, 2
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TTF1 transcription termination factor, RNA polymerase I
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF331 zinc finger protein 331
Funding