| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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402 genes differentially expressed following the BRD-K21680192_mitoxantrone_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABAT | 4-aminobutyrate aminotransferase |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
| ABHD4 | abhydrolase domain containing 4 |
| ACKR3 | atypical chemokine receptor 3 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta |
| ADIRF | adipogenesis regulatory factor |
| AMACR | alpha-methylacyl-CoA racemase |
| ANKRD36B | ankyrin repeat domain 36B |
| AREG | amphiregulin |
| ATF3 | activating transcription factor 3 |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 |
| BASP1 | brain abundant, membrane attached signal protein 1 |
| BDKRB2 | bradykinin receptor B2 |
| BHLHE41 | basic helix-loop-helix family, member e41 |
| BIK | BCL2-interacting killer (apoptosis-inducing) |
| BIRC3 | baculoviral IAP repeat containing 3 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
| BTG1 | B-cell translocation gene 1, anti-proliferative |
| BTG2 | BTG family, member 2 |
| C1R | complement component 1, r subcomponent |
| C1RL | complement component 1, r subcomponent-like |
| C8ORF4 | chromosome 8 open reading frame 4 |
| CALCOCO1 | calcium binding and coiled-coil domain 1 |
| CAPN1 | calpain 1, (mu/I) large subunit |
| CCNG2 | cyclin G2 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| CD59 | CD59 molecule, complement regulatory protein |
| CD9 | CD9 molecule |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 |
| CFB | complement factor B |
| CFLAR | CASP8 and FADD-like apoptosis regulator |
| CLDN1 | claudin 1 |
| CLU | clusterin |
| COL4A5 | collagen, type IV, alpha 5 |
| CRIP1 | cysteine-rich protein 1 (intestinal) |
| CTSB | cathepsin B |
| CTSS | cathepsin S |
| CXADR | coxsackie virus and adenovirus receptor |
| DACH1 | dachshund family transcription factor 1 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
| DEFB1 | defensin, beta 1 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 |
| DRAM1 | DNA-damage regulated autophagy modulator 1 |
| DSP | desmoplakin |
| EFNA1 | ephrin-A1 |
| EHD3 | EH-domain containing 3 |
| EPHA3 | EPH receptor A3 |
| EPS8L2 | EPS8-like 2 |
| F13A1 | coagulation factor XIII, A1 polypeptide |
| FABP4 | fatty acid binding protein 4, adipocyte |
| FADS3 | fatty acid desaturase 3 |
| FAM134A | family with sequence similarity 134, member A |
| FAM46A | family with sequence similarity 46, member A |
| FAS | Fas cell surface death receptor |
| FBLN1 | fibulin 1 |
| FDXR | ferredoxin reductase |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) |
| FN1 | fibronectin 1 |
| FOLR1 | folate receptor 1 (adult) |
| FOSL2 | FOS-like antigen 2 |
| FTH1 | ferritin, heavy polypeptide 1 |
| GAA | glucosidase, alpha; acid |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha |
| GAS6 | growth arrest-specific 6 |
| GDF15 | growth differentiation factor 15 |
| GJA1 | gap junction protein, alpha 1, 43kDa |
| GOLGA8A | golgin A8 family, member A |
| GOLGA8B | golgin A8 family, member B |
| GRN | granulin |
| GSN | gelsolin |
| GUSBP3 | glucuronidase, beta pseudogene 3 |
| HIST1H1C | histone cluster 1, H1c |
| HIST1H2AC | histone cluster 1, H2ac |
| HIST1H2BD | histone cluster 1, H2bd |
| HIST1H2BK | histone cluster 1, H2bk |
| HLA-B | major histocompatibility complex, class I, B |
| HLA-C | major histocompatibility complex, class I, C |
| HLA-E | major histocompatibility complex, class I, E |
| HLA-G | major histocompatibility complex, class I, G |
| HSPB8 | heat shock 22kDa protein 8 |
| ICAM1 | intercellular adhesion molecule 1 |
| IDS | iduronate 2-sulfatase |
| IDUA | iduronidase, alpha-L- |
| IER5 | immediate early response 5 |
| IFI27 | interferon, alpha-inducible protein 27 |
| IFI6 | interferon, alpha-inducible protein 6 |
| IFIH1 | interferon induced with helicase C domain 1 |
| IFITM1 | interferon induced transmembrane protein 1 |
| IGFBP3 | insulin-like growth factor binding protein 3 |
| IGFBP7 | insulin-like growth factor binding protein 7 |
| IL1B | interleukin 1, beta |
| INSIG2 | insulin induced gene 2 |
| IRF6 | interferon regulatory factor 6 |
| IRF9 | interferon regulatory factor 9 |
| ISCU | iron-sulfur cluster assembly enzyme |
| ISG15 | ISG15 ubiquitin-like modifier |
| ITGAV | integrin, alpha V |
| ITGB4 | integrin, beta 4 |
| JAG1 | jagged 1 |
| KLF4 | Kruppel-like factor 4 (gut) |
| KRT14 | keratin 14, type I |
| KRT19 | keratin 19, type I |
| KRT23 | keratin 23, type I |
| KRT6A | keratin 6A, type II |
| KYNU | kynureninase |
| LAMB3 | laminin, beta 3 |
| LAMC2 | laminin, gamma 2 |
| LEPROT | leptin receptor overlapping transcript |
| LMO3 | LIM domain only 3 (rhombotin-like 2) |
| LOC100272216 | uncharacterized LOC100272216 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 |
| LTBP1 | latent transforming growth factor beta binding protein 1 |
| LY75 | lymphocyte antigen 75 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MIR22HG | MIR22 host gene |
| MME | membrane metallo-endopeptidase |
| MTSS1 | metastasis suppressor 1 |
| MUC1 | mucin 1, cell surface associated |
| NCF2 | neutrophil cytosolic factor 2 |
| NMRK1 | nicotinamide riboside kinase 1 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 |
| NRIP1 | nuclear receptor interacting protein 1 |
| OPTN | optineurin |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
| PERP | PERP, TP53 apoptosis effector |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 |
| PI3 | peptidase inhibitor 3, skin-derived |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 |
| PINK1 | PTEN induced putative kinase 1 |
| PLD3 | phospholipase D family, member 3 |
| PLEK | pleckstrin |
| PNRC1 | proline-rich nuclear receptor coactivator 1 |
| PPL | periplakin |
| PRAF2 | PRA1 domain family, member 2 |
| PSAP | prosaposin |
| PTGES | prostaglandin E synthase |
| PTN | pleiotrophin |
| RABAC1 | Rab acceptor 1 (prenylated) |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 |
| RB1CC1 | RB1-inducible coiled-coil 1 |
| RBKS | ribokinase |
| RPS27L | ribosomal protein S27-like |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 |
| S100A4 | S100 calcium binding protein A4 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) |
| SDC4 | syndecan 4 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) |
| SERINC1 | serine incorporator 1 |
| SESN1 | sestrin 1 |
| SFN | stratifin |
| SH3BGRL | SH3 domain binding glutamate-rich protein like |
| SIK1 | salt-inducible kinase 1 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| SLC22A18 | solute carrier family 22, member 18 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 |
| SOD2 | superoxide dismutase 2, mitochondrial |
| SOX9 | SRY (sex determining region Y)-box 9 |
| SPATA20 | spermatogenesis associated 20 |
| SPG11 | spastic paraplegia 11 (autosomal recessive) |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa |
| STOM | stomatin |
| STXBP2 | syntaxin binding protein 2 |
| SULF1 | sulfatase 1 |
| SYBU | syntabulin (syntaxin-interacting) |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
| TBX3 | T-box 3 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase |
| TM2D1 | TM2 domain containing 1 |
| TMEM45A | transmembrane protein 45A |
| TMEM59 | transmembrane protein 59 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b |
| TNIP1 | TNFAIP3 interacting protein 1 |
| TNS3 | tensin 3 |
| TOB1 | transducer of ERBB2, 1 |
| TP53I3 | tumor protein p53 inducible protein 3 |
| TP53TG1 | TP53 target 1 (non-protein coding) |
| TRIM22 | tripartite motif containing 22 |
| TRIM29 | tripartite motif containing 29 |
| VNN1 | vanin 1 |
| WDR45 | WD repeat domain 45 |
| YPEL5 | yippee-like 5 (Drosophila) |
| ZMAT3 | zinc finger, matrin-type 3 |
| ZNF91 | zinc finger protein 91 |
| Symbol | Name |
|---|---|
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
| ASF1B | anti-silencing function 1B histone chaperone |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
| ATAD2 | ATPase family, AAA domain containing 2 |
| AURKA | aurora kinase A |
| AURKB | aurora kinase B |
| BIRC5 | baculoviral IAP repeat containing 5 |
| BLMH | bleomycin hydrolase |
| BRCA1 | breast cancer 1, early onset |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase |
| C1QBP | complement component 1, q subcomponent binding protein |
| CCNA2 | cyclin A2 |
| CCNB1 | cyclin B1 |
| CCNB2 | cyclin B2 |
| CCNF | cyclin F |
| CDC20 | cell division cycle 20 |
| CDC25A | cell division cycle 25A |
| CDC45 | cell division cycle 45 |
| CDC6 | cell division cycle 6 |
| CDCA3 | cell division cycle associated 3 |
| CDCA4 | cell division cycle associated 4 |
| CDCA8 | cell division cycle associated 8 |
| CDK1 | cyclin-dependent kinase 1 |
| CDK4 | cyclin-dependent kinase 4 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 |
| CDT1 | chromatin licensing and DNA replication factor 1 |
| CENPA | centromere protein A |
| CENPE | centromere protein E, 312kDa |
| CENPF | centromere protein F, 350/400kDa |
| CENPN | centromere protein N |
| CENPU | centromere protein U |
| CEP55 | centrosomal protein 55kDa |
| CHEK2 | checkpoint kinase 2 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B |
| CKS2 | CDC28 protein kinase regulatory subunit 2 |
| COTL1 | coactosin-like F-actin binding protein 1 |
| CRTAP | cartilage associated protein |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) |
| CXCL14 | chemokine (C-X-C motif) ligand 14 |
| DBF4 | DBF4 zinc finger |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 |
| DEPDC1 | DEP domain containing 1 |
| DHFR | dihydrofolate reductase |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
| DNAJC9 | DnaJ (Hsp40) homolog, subfamily C, member 9 |
| DONSON | downstream neighbor of SON |
| DSCC1 | DNA replication and sister chromatid cohesion 1 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DUT | deoxyuridine triphosphatase |
| ECT2 | epithelial cell transforming 2 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 |
| EIF5A | eukaryotic translation initiation factor 5A |
| ELAVL1 | ELAV like RNA binding protein 1 |
| EMX2 | empty spiracles homeobox 2 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) |
| EXO1 | exonuclease 1 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
| FAM64A | family with sequence similarity 64, member A |
| FANCI | Fanconi anemia, complementation group I |
| FBL | fibrillarin |
| FBXO5 | F-box protein 5 |
| FEN1 | flap structure-specific endonuclease 1 |
| FOXM1 | forkhead box M1 |
| FXYD2 | FXYD domain containing ion transport regulator 2 |
| GAL | galanin/GMAP prepropeptide |
| GCH1 | GTP cyclohydrolase 1 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GPD1L | glycerol-3-phosphate dehydrogenase 1-like |
| GPHN | gephyrin |
| GTSE1 | G-2 and S-phase expressed 1 |
| H2AFX | H2A histone family, member X |
| HAT1 | histone acetyltransferase 1 |
| HJURP | Holliday junction recognition protein |
| HMGB2 | high mobility group box 2 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) |
| HOXC6 | homeobox C6 |
| KIAA0101 | KIAA0101 |
| KIF11 | kinesin family member 11 |
| KIF14 | kinesin family member 14 |
| KIF15 | kinesin family member 15 |
| KIF18B | kinesin family member 18B |
| KIF20A | kinesin family member 20A |
| KIF23 | kinesin family member 23 |
| KIF4A | kinesin family member 4A |
| KIFC1 | kinesin family member C1 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
| LAMP5 | lysosomal-associated membrane protein family, member 5 |
| LBR | lamin B receptor |
| LDHB | lactate dehydrogenase B |
| LEF1 | lymphoid enhancer-binding factor 1 |
| LMNB1 | lamin B1 |
| LMNB2 | lamin B2 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| LTF | lactotransferrin |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| MAMLD1 | mastermind-like domain containing 1 |
| MCAM | melanoma cell adhesion molecule |
| MCM10 | minichromosome maintenance complex component 10 |
| MCM2 | minichromosome maintenance complex component 2 |
| MCM3 | minichromosome maintenance complex component 3 |
| MCM4 | minichromosome maintenance complex component 4 |
| MCM6 | minichromosome maintenance complex component 6 |
| MCM7 | minichromosome maintenance complex component 7 |
| MELK | maternal embryonic leucine zipper kinase |
| MGP | matrix Gla protein |
| MIS18A | MIS18 kinetochore protein A |
| MKI67 | marker of proliferation Ki-67 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| NCAPG | non-SMC condensin I complex, subunit G |
| NCAPG2 | non-SMC condensin II complex, subunit G2 |
| NCAPH | non-SMC condensin I complex, subunit H |
| NDC80 | NDC80 kinetochore complex component |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) |
| NEK2 | NIMA-related kinase 2 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 |
| NFIB | nuclear factor I/B |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) |
| NPM3 | nucleophosmin/nucleoplasmin 3 |
| NPY | neuropeptide Y |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 |
| NUSAP1 | nucleolar and spindle associated protein 1 |
| OIP5 | Opa interacting protein 5 |
| OLFM4 | olfactomedin 4 |
| ORC6 | origin recognition complex, subunit 6 |
| PA2G4 | proliferation-associated 2G4, 38kDa |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase |
| PARP2 | poly (ADP-ribose) polymerase 2 |
| PBK | PDZ binding kinase |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha |
| PDLIM3 | PDZ and LIM domain 3 |
| PDZRN3 | PDZ domain containing ring finger 3 |
| PFAS | phosphoribosylformylglycinamidine synthase |
| PHGDH | phosphoglycerate dehydrogenase |
| PLK1 | polo-like kinase 1 |
| POLD2 | polymerase (DNA directed), delta 2, accessory subunit |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
| POLR3K | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa |
| PRC1 | protein regulator of cytokinesis 1 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) |
| PSAT1 | phosphoserine aminotransferase 1 |
| PSPH | phosphoserine phosphatase |
| PTTG1 | pituitary tumor-transforming 1 |
| RACGAP1 | Rac GTPase activating protein 1 |
| RANBP1 | RAN binding protein 1 |
| RFC2 | replication factor C (activator 1) 2, 40kDa |
| RFC3 | replication factor C (activator 1) 3, 38kDa |
| RFC4 | replication factor C (activator 1) 4, 37kDa |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa |
| RHOBTB3 | Rho-related BTB domain containing 3 |
| RNASEH2A | ribonuclease H2, subunit A |
| RPS11 | ribosomal protein S11 |
| RRM1 | ribonucleotide reductase M1 |
| RRM2 | ribonucleotide reductase M2 |
| SAP30 | Sin3A-associated protein, 30kDa |
| SFRP1 | secreted frizzled-related protein 1 |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| SLC29A1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 |
| SMC1A | structural maintenance of chromosomes 1A |
| SMC4 | structural maintenance of chromosomes 4 |
| SNRPA | small nuclear ribonucleoprotein polypeptide A |
| SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide 16kDa |
| SPAG5 | sperm associated antigen 5 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) |
| SPC25 | SPC25, NDC80 kinetochore complex component |
| SPDL1 | spindle apparatus coiled-coil protein 1 |
| SPON1 | spondin 1, extracellular matrix protein |
| SRM | spermidine synthase |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 |
| STMN1 | stathmin 1 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| TACC3 | transforming, acidic coiled-coil containing protein 3 |
| TFDP1 | transcription factor Dp-1 |
| TIMELESS | timeless circadian clock |
| TIPIN | TIMELESS interacting protein |
| TK1 | thymidine kinase 1, soluble |
| TMEM97 | transmembrane protein 97 |
| TMPO | thymopoietin |
| TOP2A | topoisomerase (DNA) II alpha 170kDa |
| TPX2 | TPX2, microtubule-associated |
| TRIP13 | thyroid hormone receptor interactor 13 |
| TRMT5 | tRNA methyltransferase 5 |
| TROAP | trophinin associated protein |
| TTK | TTK protein kinase |
| TUBB | tubulin, beta class I |
| TYMS | thymidylate synthetase |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| VRK1 | vaccinia related kinase 1 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) |
| ZDHHC6 | zinc finger, DHHC-type containing 6 |
| ZWINT | ZW10 interacting kinetochore protein |
