BRD-K21680192_mitoxantrone_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

327 genes differentially expressed following the BRD-K21680192_mitoxantrone_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADORA2B adenosine A2b receptor
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
APOC2 apolipoprotein C-II
APOD apolipoprotein D
AREG amphiregulin
ARG2 arginase 2
ATF3 activating transcription factor 3
ATP10B ATPase, class V, type 10B
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AXL AXL receptor tyrosine kinase
BCHE butyrylcholinesterase
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CAST calpastatin
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CD81 CD81 molecule
CD9 CD9 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHN1 chimerin 1
CLGN calmegin
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL13A1 collagen, type XIII, alpha 1
COLEC12 collectin sub-family member 12
COMP cartilage oligomeric matrix protein
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
CPE carboxypeptidase E
CPM carboxypeptidase M
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTSB cathepsin B
CTSK cathepsin K
CTSL cathepsin L
CTSS cathepsin S
CXADR coxsackie virus and adenovirus receptor
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP10 dual specificity phosphatase 10
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FST follistatin
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GM2A GM2 ganglioside activator
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF4 Kruppel-like factor 4 (gut)
LBH limb bud and heart development
LGALS1 lectin, galactoside-binding, soluble, 1
LGMN legumain
LIMCH1 LIM and calponin homology domains 1
LOC100272216 uncharacterized LOC100272216
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MAOA monoamine oxidase A
MCOLN1 mucolipin 1
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSLN mesothelin
MT1X metallothionein 1X
MYO1B myosin IB
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NPDC1 neural proliferation, differentiation and control, 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OPHN1 oligophrenin 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PALLD palladin, cytoskeletal associated protein
PCCA propionyl CoA carboxylase, alpha polypeptide
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PFKM phosphofructokinase, muscle
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAU plasminogen activator, urokinase
PLD3 phospholipase D family, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRAME preferentially expressed antigen in melanoma
PRNP prion protein
PRSS21 protease, serine, 21 (testisin)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTCH1 patched 1
PVALB parvalbumin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPRY4 sprouty homolog 4 (Drosophila)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STC1 stanniocalcin 1
STOM stomatin
SULF1 sulfatase 1
TGFA transforming growth factor, alpha
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TP53I3 tumor protein p53 inducible protein 3
TP53TG1 TP53 target 1 (non-protein coding)
TRIM22 tripartite motif containing 22
TSPAN12 tetraspanin 12
TSPAN3 tetraspanin 3
TSPAN4 tetraspanin 4
TSPAN7 tetraspanin 7
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
VIM vimentin
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARMT1 acidic residue methyltransferase 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
B3GNT1
BARD1 BRCA1 associated RING domain 1
BCL2 B-cell CLL/lymphoma 2
BRCA1 breast cancer 1, early onset
C14ORF169 chromosome 14 open reading frame 169
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CPD carboxypeptidase D
CREB1 cAMP responsive element binding protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DBF4 DBF4 zinc finger
DEPTOR DEP domain containing MTOR-interacting protein
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
E2F8 E2F transcription factor 8
ELANE elastase, neutrophil expressed
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGBP Fc fragment of IgG binding protein
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FMO5 flavin containing monooxygenase 5
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GLOD4 glyoxalase domain containing 4
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GREB1 growth regulation by estrogen in breast cancer 1
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IGKC immunoglobulin kappa constant
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
LMNB1 lamin B1
LTF lactotransferrin
MAPK6 mitogen-activated protein kinase 6
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MNDA myeloid cell nuclear differentiation antigen
MREG melanoregulin
MSH6 mutS homolog 6
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NET1 neuroepithelial cell transforming 1
NFYA nuclear transcription factor Y, alpha
NOL11 nucleolar protein 11
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PDS5A PDS5 cohesin associated factor A
PDZK1 PDZ domain containing 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PUF60 poly-U binding splicing factor 60KDa
QKI QKI, KH domain containing, RNA binding
RFC3 replication factor C (activator 1) 3, 38kDa
S100A12 S100 calcium binding protein A12
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1
SMAD1 SMAD family member 1
SMC3 structural maintenance of chromosomes 3
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBL1X transducin (beta)-like 1X-linked
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR4 toll-like receptor 4
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
TUBB tubulin, beta class I
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VANGL1 VANGL planar cell polarity protein 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZNF146 zinc finger protein 146
ZNF217 zinc finger protein 217
Funding