BRD-K21680192_mitoxantrone_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K21680192_mitoxantrone_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAMBI BMP and activin membrane-bound inhibitor
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
CBR3 carbonyl reductase 3
CCL4 chemokine (C-C motif) ligand 4
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD48 CD48 molecule
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COLEC12 collectin sub-family member 12
CPM carboxypeptidase M
CTSS cathepsin S
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5A cytochrome b5 type A (microsomal)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DSP desmoplakin
DUSP2 dual specificity phosphatase 2
EFS embryonal Fyn-associated substrate
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM117A family with sequence similarity 117, member A
FKBP14 FK506 binding protein 14, 22 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GLRX glutaredoxin (thioltransferase)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN5 high mobility group nucleosome binding domain 5
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ICAM1 intercellular adhesion molecule 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
ITM2A integral membrane protein 2A
JAG1 jagged 1
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT17 keratin 17, type I
LDB2 LIM domain binding 2
LITAF lipopolysaccharide-induced TNF factor
MCOLN1 mucolipin 1
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPN3 opsin 3
PERP PERP, TP53 apoptosis effector
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLVAP plasmalemma vesicle associated protein
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLPI secretory leukocyte peptidase inhibitor
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SNAP25 synaptosomal-associated protein, 25kDa
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
SQLE squalene epoxidase
TBX3 T-box 3
TCF4 transcription factor 4
THAP11 THAP domain containing 11
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
UBL5 ubiquitin-like 5
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABR active BCR-related
ADSL adenylosuccinate lyase
AHNAK AHNAK nucleoprotein
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANXA3 annexin A3
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AREG amphiregulin
AXL AXL receptor tyrosine kinase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNA2 cyclin A2
CCND1 cyclin D1
CDC42 cell division cycle 42
CDCP1 CUB domain containing protein 1
CEP55 centrosomal protein 55kDa
CTSB cathepsin B
DERA deoxyribose-phosphate aldolase (putative)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DPYD dihydropyrimidine dehydrogenase
DUSP3 dual specificity phosphatase 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EREG epiregulin
ERLIN1 ER lipid raft associated 1
FGFR3 fibroblast growth factor receptor 3
FLNB filamin B, beta
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GMDS GDP-mannose 4,6-dehydratase
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
IGFBP7 insulin-like growth factor binding protein 7
IL32 interleukin 32
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
LASP1 LIM and SH3 protein 1
MACF1 microtubule-actin crosslinking factor 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MED13L mediator complex subunit 13-like
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKI67 marker of proliferation Ki-67
MYOF myoferlin
NET1 neuroepithelial cell transforming 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP85 nucleoporin 85kDa
PAM peptidylglycine alpha-amidating monooxygenase
PLAC8 placenta-specific 8
PODXL podocalyxin-like
PRKCA protein kinase C, alpha
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
RGS10 regulator of G-protein signaling 10
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMS spermine synthase
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGM2 transglutaminase 2
TRAF3 TNF receptor-associated factor 3
TRAM2 translocation associated membrane protein 2
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VDAC1 voltage-dependent anion channel 1
XPO7 exportin 7
Funding