BRD-K21680192_mitoxantrone_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

441 genes differentially expressed following the BRD-K21680192_mitoxantrone_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
AGO3 argonaute RISC catalytic component 3
AHR aryl hydrocarbon receptor
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AMOTL2 angiomotin like 2
APOLD1 apolipoprotein L domain containing 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP10D ATPase, class V, type 10D
BAMBI BMP and activin membrane-bound inhibitor
BCAM basal cell adhesion molecule (Lutheran blood group)
BCHE butyrylcholinesterase
BNC2 basonuclin 2
BRD2 bromodomain containing 2
BSG basigin (Ok blood group)
BTG3 BTG family, member 3
CA11 carbonic anhydrase XI
CBR3 carbonyl reductase 3
CBX4 chromobox homolog 4
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL4 chemokine (C-C motif) ligand 4
CCL8 chemokine (C-C motif) ligand 8
CCNE2 cyclin E2
CD200 CD200 molecule
CD9 CD9 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CHMP1B charged multivesicular body protein 1B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN1 claudin 1
CLGN calmegin
CLIC2 chloride intracellular channel 2
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CREM cAMP responsive element modulator
CST7 cystatin F (leukocystatin)
CTAG2 cancer/testis antigen 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DACH1 dachshund family transcription factor 1
DAXX death-domain associated protein
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO1 deiodinase, iodothyronine, type I
DLX2 distal-less homeobox 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPH2 DPH2 homolog (S. cerevisiae)
DUSP14 dual specificity phosphatase 14
EMX2 empty spiracles homeobox 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERLIN2 ER lipid raft associated 2
ETV5 ets variant 5
EXOSC4 exosome component 4
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FBXL12 F-box and leucine-rich repeat protein 12
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF9 fibroblast growth factor 9
FKBP14 FK506 binding protein 14, 22 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GAS1 growth arrest-specific 1
GBP1 guanylate binding protein 1, interferon-inducible
GLA galactosidase, alpha
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GREM1 gremlin 1, DAN family BMP antagonist
GTF2B general transcription factor IIB
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H2BFS H2B histone family, member S (pseudogene)
HCK HCK proto-oncogene, Src family tyrosine kinase
HECA headcase homolog (Drosophila)
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H1C histone cluster 1, H1c
HIST1H2AG histone cluster 1, H2ag
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST3H2A histone cluster 3, H2a
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLF hepatic leukemia factor
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IL6 interleukin 6
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0907 KIAA0907
KIAA1462 KIAA1462
LAMP1 lysosomal-associated membrane protein 1
LAMP3 lysosomal-associated membrane protein 3
LDB2 LIM domain binding 2
LYPD1 LY6/PLAUR domain containing 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MCOLN1 mucolipin 1
MERTK MER proto-oncogene, tyrosine kinase
MMP12 matrix metallopeptidase 12
MMP19 matrix metallopeptidase 19
MMP9 matrix metallopeptidase 9
MOSPD1 motile sperm domain containing 1
MRPL33 mitochondrial ribosomal protein L33
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MYB v-myb avian myeloblastosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEU1 sialidase 1 (lysosomal sialidase)
NID2 nidogen 2 (osteonidogen)
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OPN3 opsin 3
OSR2 odd-skipped related transciption factor 2
PCP4 Purkinje cell protein 4
PDE10A phosphodiesterase 10A
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PER2 period circadian clock 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLK2 polo-like kinase 2
PLN phospholamban
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPIF peptidylprolyl isomerase F
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRAF2 PRA1 domain family, member 2
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCH protein kinase C, eta
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP2A RAP2A, member of RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RBKS ribokinase
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
REG1A regenerating islet-derived 1 alpha
RFC2 replication factor C (activator 1) 2, 40kDa
RHOB ras homolog family member B
RIT1 Ras-like without CAAX 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF144A ring finger protein 144A
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RSL1D1 ribosomal L1 domain containing 1
RSRP1 arginine/serine-rich protein 1
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCG5 secretogranin V
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SLC38A2 solute carrier family 38, member 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOD2 superoxide dismutase 2, mitochondrial
SPAG4 sperm associated antigen 4
SPON2 spondin 2, extracellular matrix protein
SPRR2B small proline-rich protein 2B
SRSF6 serine/arginine-rich splicing factor 6
STON1 stonin 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBX2 T-box 2
TDO2 tryptophan 2,3-dioxygenase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM2 transmembrane protein 2
TMEM59 transmembrane protein 59
TOX4 TOX high mobility group box family member 4
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TRIB2 tribbles pseudokinase 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UBE3B ubiquitin protein ligase E3B
UBFD1 ubiquitin family domain containing 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
WASF1 WAS protein family, member 1
WT1 Wilms tumor 1
YBX1 Y box binding protein 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF274 zinc finger protein 274
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABR active BCR-related
ACPP acid phosphatase, prostate
ACSL3 acyl-CoA synthetase long-chain family member 3
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANXA1 annexin A1
ANXA10 annexin A10
ANXA11 annexin A11
ANXA3 annexin A3
ANXA7 annexin A7
AQP3 aquaporin 3 (Gill blood group)
ARL5A ADP-ribosylation factor-like 5A
ASCC3 activating signal cointegrator 1 complex subunit 3
AUTS2 autism susceptibility candidate 2
AXL AXL receptor tyrosine kinase
B3GNT1
BHLHE40 basic helix-loop-helix family, member e40
BIN1 bridging integrator 1
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCND1 cyclin D1
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CENPE centromere protein E, 312kDa
CFD complement factor D (adipsin)
CFH complement factor H
CHD1L chromodomain helicase DNA binding protein 1-like
CLDN18 claudin 18
COG2 component of oligomeric golgi complex 2
CRYM crystallin, mu
CXCL14 chemokine (C-X-C motif) ligand 14
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DPYSL3 dihydropyrimidinase-like 3
ECD ecdysoneless homolog (Drosophila)
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENOSF1 enolase superfamily member 1
EPRS glutamyl-prolyl-tRNA synthetase
ERO1L ERO1-like (S. cerevisiae)
F3 coagulation factor III (thromboplastin, tissue factor)
FCGBP Fc fragment of IgG binding protein
FERMT1 fermitin family member 1
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAL galanin/GMAP prepropeptide
GMDS GDP-mannose 4,6-dehydratase
GNPAT glyceronephosphate O-acyltransferase
GOLM1 golgi membrane protein 1
GSTP1 glutathione S-transferase pi 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IRAK1 interleukin-1 receptor-associated kinase 1
ITGA6 integrin, alpha 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JCHAIN joining chain of multimeric IgA and IgM
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD12 potassium channel tetramerization domain containing 12
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM5D lysine (K)-specific demethylase 5D
KIAA0368 KIAA0368
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LAMB3 laminin, beta 3
LDHB lactate dehydrogenase B
LDLR low density lipoprotein receptor
LOXL1 lysyl oxidase-like 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP1 latent transforming growth factor beta binding protein 1
LTF lactotransferrin
LYPLA1 lysophospholipase I
MALL mal, T-cell differentiation protein-like
MANSC1 MANSC domain containing 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS2 Meis homeobox 2
MGLL monoglyceride lipase
MKL2 MKL/myocardin-like 2
MLPH melanophilin
MPRIP myosin phosphatase Rho interacting protein
MSMB microseminoprotein, beta-
MT1F metallothionein 1F
MTERF3 mitochondrial transcription termination factor 3
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYOF myoferlin
NAE1 NEDD8 activating enzyme E1 subunit 1
NCK2 NCK adaptor protein 2
NCOR2 nuclear receptor corepressor 2
NEBL nebulette
NES nestin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NKX3-1 NK3 homeobox 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PAM peptidylglycine alpha-amidating monooxygenase
PAPOLA poly(A) polymerase alpha
PARP2 poly (ADP-ribose) polymerase 2
PCLO piccolo presynaptic cytomatrix protein
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDS5A PDS5 cohesin associated factor A
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP prolactin-induced protein
PIR pirin (iron-binding nuclear protein)
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLBD1 phospholipase B domain containing 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PPA1 pyrophosphatase (inorganic) 1
PPARG peroxisome proliferator-activated receptor gamma
PRKCA protein kinase C, alpha
PRSS3 protease, serine, 3
PSCA prostate stem cell antigen
PSIP1 PC4 and SFRS1 interacting protein 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PWP1 PWP1 homolog (S. cerevisiae)
PYCR1 pyrroline-5-carboxylate reductase 1
PYGB phosphorylase, glycogen; brain
QDPR quinoid dihydropteridine reductase
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RALGDS ral guanine nucleotide dissociation stimulator
RFTN1 raftlin, lipid raft linker 1
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RPS5 ribosomal protein S5
RRAS related RAS viral (r-ras) oncogene homolog
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SRI sorcin
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
STK10 serine/threonine kinase 10
STX1A syntaxin 1A (brain)
SUMO3 small ubiquitin-like modifier 3
TBC1D4 TBC1 domain family, member 4
TBC1D5 TBC1 domain family, member 5
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCEA1 transcription elongation factor A (SII), 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF2 trefoil factor 2
THBS4 thrombospondin 4
TM4SF1 transmembrane 4 L six family member 1
TM9SF3 transmembrane 9 superfamily member 3
TNIP1 TNFAIP3 interacting protein 1
TPD52 tumor protein D52
TPX2 TPX2, microtubule-associated
TRAP1 TNF receptor-associated protein 1
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TSPO translocator protein (18kDa)
TTC3 tetratricopeptide repeat domain 3
WNT5A wingless-type MMTV integration site family, member 5A
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZFP36L1 ZFP36 ring finger protein-like 1
Funding