BRD-K22010301_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K22010301_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
CA1 carbonic anhydrase I
CD163 CD163 molecule
CD300A CD300a molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CREM cAMP responsive element modulator
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK5 docking protein 5
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
FXYD6 FXYD domain containing ion transport regulator 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
H2BFS H2B histone family, member S (pseudogene)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IL10RA interleukin 10 receptor, alpha
KLF11 Kruppel-like factor 11
LY96 lymphocyte antigen 96
MAOB monoamine oxidase B
MEG3 maternally expressed 3 (non-protein coding)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
OSER1 oxidative stress responsive serine-rich 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
RNMT RNA (guanine-7-) methyltransferase
S100A8 S100 calcium binding protein A8
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
TANK TRAF family member-associated NFKB activator
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
TYROBP TYRO protein tyrosine kinase binding protein
ZFP36 ZFP36 ring finger protein
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
ALCAM activated leukocyte cell adhesion molecule
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
CALD1 caldesmon 1
CCNA2 cyclin A2
CCND1 cyclin D1
CDC25B cell division cycle 25B
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
COL4A2 collagen, type IV, alpha 2
CTSC cathepsin C
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GTSE1 G-2 and S-phase expressed 1
IGFBP3 insulin-like growth factor binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MET MET proto-oncogene, receptor tyrosine kinase
MKI67 marker of proliferation Ki-67
MOK MOK protein kinase
MRPL12 mitochondrial ribosomal protein L12
MYOF myoferlin
NFIB nuclear factor I/B
OXLD1 oxidoreductase-like domain containing 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
PPAP2C phosphatidic acid phosphatase type 2C
PPARG peroxisome proliferator-activated receptor gamma
PRAME preferentially expressed antigen in melanoma
PRSS23 protease, serine, 23
RHOBTB3 Rho-related BTB domain containing 3
S100A10 S100 calcium binding protein A10
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
Funding