BRD-K22215695_1-(4-methylbenzyl)-4-[4-(2-methylphenyl)-1-piperazinyl]-1H-pyrazolo[3,4-d]pyrimidine_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K22215695_1-(4-methylbenzyl)-4-[4-(2-methylphenyl)-1-piperazinyl]-1H-pyrazolo[3,4-d]pyrimidine_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASPN asporin
ASS1 argininosuccinate synthase 1
BEX4 brain expressed, X-linked 4
C14ORF132 chromosome 14 open reading frame 132
CD200 CD200 molecule
CD93 CD93 molecule
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL8A2 collagen, type VIII, alpha 2
COLEC12 collectin sub-family member 12
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
FCGBP Fc fragment of IgG binding protein
GPNMB glycoprotein (transmembrane) nmb
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LCN2 lipocalin 2
LIMCH1 LIM and calponin homology domains 1
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
METRN meteorin, glial cell differentiation regulator
MN1 meningioma (disrupted in balanced translocation) 1
MXRA5 matrix-remodelling associated 5
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PECAM1 platelet/endothelial cell adhesion molecule 1
RAB31 RAB31, member RAS oncogene family
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
SRGN serglycin
SULF1 sulfatase 1
TPPP3 tubulin polymerization-promoting protein family member 3
TSPAN7 tetraspanin 7
ZFPM2 zinc finger protein, FOG family member 2
ZIC1 Zic family member 1

decreased expression

Symbol Name
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CCL19 chemokine (C-C motif) ligand 19
CD59 CD59 molecule, complement regulatory protein
CHIC2 cysteine-rich hydrophobic domain 2
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
EGFR epidermal growth factor receptor
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HOXC6 homeobox C6
IGHM immunoglobulin heavy constant mu
JMJD6 jumonji domain containing 6
KDM4B lysine (K)-specific demethylase 4B
LAMP1 lysosomal-associated membrane protein 1
LTF lactotransferrin
MMP7 matrix metallopeptidase 7
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
SAP30 Sin3A-associated protein, 30kDa
SFRP1 secreted frizzled-related protein 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TCL1A T-cell leukemia/lymphoma 1A
UBE2S ubiquitin-conjugating enzyme E2S
ZBTB38 zinc finger and BTB domain containing 38
Funding