BRD-K22988559_N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-[(phenylsulfonyl)amino]benzamide_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

62 genes differentially expressed following the BRD-K22988559_N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-[(phenylsulfonyl)amino]benzamide_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
APOD apolipoprotein D
CLC Charcot-Leyden crystal galectin
CPM carboxypeptidase M
CTGF connective tissue growth factor
CTSB cathepsin B
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
ESR1 estrogen receptor 1
FBLN1 fibulin 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPM6B glycoprotein M6B
GSN gelsolin
HCAR3 hydroxycarboxylic acid receptor 3
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LTF lactotransferrin
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NPTX2 neuronal pentraxin II
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OLFM4 olfactomedin 4
RCAN1 regulator of calcineurin 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RTN1 reticulon 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPP1 selenoprotein P, plasma, 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLPI secretory leukocyte peptidase inhibitor
TARP TCR gamma alternate reading frame protein
TCF4 transcription factor 4
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TRD T cell receptor delta locus
TXNL1 thioredoxin-like 1
WDR7 WD repeat domain 7

decreased expression

Symbol Name
AREG amphiregulin
AUTS2 autism susceptibility candidate 2
C6ORF62 chromosome 6 open reading frame 62
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CYCS cytochrome c, somatic
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM69A family with sequence similarity 69, member A
GATA6 GATA binding protein 6
GSTP1 glutathione S-transferase pi 1
ISG15 ISG15 ubiquitin-like modifier
LAPTM4B lysosomal protein transmembrane 4 beta
PEG10 paternally expressed 10
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TMEM176B transmembrane protein 176B
Funding