BRD-K23165181_NCGC00241357-01_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

233 genes differentially expressed following the BRD-K23165181_NCGC00241357-01_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ACOT7 acyl-CoA thioesterase 7
ACSF2 acyl-CoA synthetase family member 2
ADCY9 adenylate cyclase 9
AGTPBP1 ATP/GTP binding protein 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
ANXA6 annexin A6
AOX1 aldehyde oxidase 1
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASMTL acetylserotonin O-methyltransferase-like
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BAG3 BCL2-associated athanogene 3
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF16 chromosome 9 open reading frame 16
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CCNG2 cyclin G2
CD81 CD81 molecule
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L2 chitinase 3-like 2
CIB1 calcium and integrin binding 1 (calmyrin)
CLDN10 claudin 10
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
CPD carboxypeptidase D
CRAT carnitine O-acetyltransferase
CRIP1 cysteine-rich protein 1 (intestinal)
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSH cathepsin H
CTSV cathepsin V
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSTN destrin (actin depolymerizing factor)
ECHDC3 enoyl CoA hydratase domain containing 3
FAM117A family with sequence similarity 117, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GMCL1 germ cell-less, spermatogenesis associated 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
H1F0 H1 histone family, member 0
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HLTF helicase-like transcription factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOXC10 homeobox C10
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IL32 interleukin 32
INSIG1 insulin induced gene 1
IQCG IQ motif containing G
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITM2A integral membrane protein 2A
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCTD5 potassium channel tetramerization domain containing 5
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
LITAF lipopolysaccharide-induced TNF factor
LPIN1 lipin 1
MAGEB2 melanoma antigen family B2
METRN meteorin, glial cell differentiation regulator
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MICB MHC class I polypeptide-related sequence B
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLF1 myeloid leukemia factor 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NDRG3 NDRG family member 3
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NOSIP nitric oxide synthase interacting protein
OAT ornithine aminotransferase
OSBPL8 oxysterol binding protein-like 8
OSR2 odd-skipped related transciption factor 2
OSTM1 osteopetrosis associated transmembrane protein 1
PALLD palladin, cytoskeletal associated protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PHF20 PHD finger protein 20
PLA2G15 phospholipase A2, group XV
PRDX1 peroxiredoxin 1
PRKCD protein kinase C, delta
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPCT glutaminyl-peptide cyclotransferase
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RBP1 retinol binding protein 1, cellular
RHOB ras homolog family member B
RIMS3 regulating synaptic membrane exocytosis 3
RIOK3 RIO kinase 3
ROGDI rogdi homolog (Drosophila)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RUNX3 runt-related transcription factor 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SEPHS2 selenophosphate synthetase 2
SEPT6 septin 6
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNAP23 synaptosomal-associated protein, 23kDa
SNN stannin
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STK3 serine/threonine kinase 3
STOM stomatin
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TRAK2 trafficking protein, kinesin binding 2
TRAM1 translocation associated membrane protein 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TUFT1 tuftelin 1
VAT1 vesicle amine transport 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA10 annexin A10
ARID1A AT rich interactive domain 1A (SWI-like)
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
C3ORF14 chromosome 3 open reading frame 14
CCNA2 cyclin A2
CCND2 cyclin D2
CD200 CD200 molecule
CFI complement factor I
CIAPIN1 cytokine induced apoptosis inhibitor 1
CPE carboxypeptidase E
CTSS cathepsin S
CXCL11 chemokine (C-X-C motif) ligand 11
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYTIP cytohesin 1 interacting protein
DENND2D DENN/MADD domain containing 2D
DPYSL3 dihydropyrimidinase-like 3
EGFR epidermal growth factor receptor
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM129A family with sequence similarity 129, member A
FAM60A family with sequence similarity 60, member A
FERMT1 fermitin family member 1
FOSL1 FOS-like antigen 1
GPNMB glycoprotein (transmembrane) nmb
GPR171 G protein-coupled receptor 171
GPX2 glutathione peroxidase 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IL1R2 interleukin 1 receptor, type II
IL7R interleukin 7 receptor
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LCN2 lipocalin 2
LMNB1 lamin B1
LTF lactotransferrin
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MRPS18B mitochondrial ribosomal protein S18B
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
MYOF myoferlin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PLN phospholamban
PNN pinin, desmosome associated protein
PON2 paraoxonase 2
PSCA prostate stem cell antigen
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
RPL10 ribosomal protein L10
RTP4 receptor (chemosensory) transporter protein 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC35F2 solute carrier family 35, member F2
SMAGP small cell adhesion glycoprotein
SOX17 SRY (sex determining region Y)-box 17
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SRSF5 serine/arginine-rich splicing factor 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCERG1 transcription elongation regulator 1
TDO2 tryptophan 2,3-dioxygenase
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP1 ubiquitin specific peptidase 1
VWF von Willebrand factor
ZBTB20 zinc finger and BTB domain containing 20
Funding