BRD-K23192422_L-6307_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-K23192422_L-6307_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
AHCY adenosylhomocysteinase
ANOS1 anosmin 1
APP amyloid beta (A4) precursor protein
ASPN asporin
ASS1 argininosuccinate synthase 1
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CCDC92 coiled-coil domain containing 92
CCL5 chemokine (C-C motif) ligand 5
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL8A2 collagen, type VIII, alpha 2
COLEC12 collectin sub-family member 12
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FRZB frizzled-related protein
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSPT2 G1 to S phase transition 2
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IL32 interleukin 32
KRT13 keratin 13, type I
KRT19 keratin 19, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS4 lectin, galactoside-binding, soluble, 4
LITAF lipopolysaccharide-induced TNF factor
METTL7A methyltransferase like 7A
MMP12 matrix metallopeptidase 12
MN1 meningioma (disrupted in balanced translocation) 1
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MSLN mesothelin
MXRA5 matrix-remodelling associated 5
NPTX2 neuronal pentraxin II
NUCB1 nucleobindin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
OPTN optineurin
ORM1 orosomucoid 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRL platelet-derived growth factor receptor-like
PEG3 paternally expressed 3
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLD3 phospholipase D family, member 3
PLTP phospholipid transfer protein
PPIF peptidylprolyl isomerase F
PSAP prosaposin
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRO protein tyrosine phosphatase, receptor type, O
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SOD2 superoxide dismutase 2, mitochondrial
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STON1 stonin 1
SULF1 sulfatase 1
SYNPO synaptopodin
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOX thymocyte selection-associated high mobility group box
TSPAN7 tetraspanin 7
VCAM1 vascular cell adhesion molecule 1
WISP2 WNT1 inducible signaling pathway protein 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BMPR1A bone morphogenetic protein receptor, type IA
BTG1 B-cell translocation gene 1, anti-proliferative
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CCNF cyclin F
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CNN1 calponin 1, basic, smooth muscle
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAAM1 dishevelled associated activator of morphogenesis 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDNRB endothelin receptor type B
EIF4A1 eukaryotic translation initiation factor 4A1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
F5 coagulation factor V (proaccelerin, labile factor)
FAM111A family with sequence similarity 111, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD5 FXYD domain containing ion transport regulator 5
FZD7 frizzled class receptor 7
GSAP gamma-secretase activating protein
HAPLN1 hyaluronan and proteoglycan link protein 1
HAS2 hyaluronan synthase 2
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOMER1 homer scaffolding protein 1
HOXB7 homeobox B7
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
KRT1 keratin 1, type II
LEF1 lymphoid enhancer-binding factor 1
LOR loricrin
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MGLL monoglyceride lipase
MLANA melan-A
MNAT1 MNAT CDK-activating kinase assembly factor 1
MTCL1 microtubule crosslinking factor 1
MYO10 myosin X
NAV3 neuron navigator 3
NCALD neurocalcin delta
NET1 neuroepithelial cell transforming 1
NPY neuropeptide Y
NTS neurotensin
OXTR oxytocin receptor
PCDH9 protocadherin 9
PDLIM5 PDZ and LIM domain 5
PHACTR2 phosphatase and actin regulator 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PLS1 plastin 1
PODXL podocalyxin-like
PRKCD protein kinase C, delta
PROM1 prominin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RDX radixin
RGS4 regulator of G-protein signaling 4
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SERINC5 serine incorporator 5
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
SVIL supervillin
TBC1D4 TBC1 domain family, member 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
TMEM2 transmembrane protein 2
TNC tenascin C
TRAK2 trafficking protein, kinesin binding 2
TXNRD1 thioredoxin reductase 1
UGCG UDP-glucose ceramide glucosyltransferase
VCAN versican
WWTR1 WW domain containing transcription regulator 1
ZBTB38 zinc finger and BTB domain containing 38
ZMYND8 zinc finger, MYND-type containing 8
Funding