BRD-K23282736_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K23282736_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGAP29 Rho GTPase activating protein 29
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
CD52 CD52 molecule
CD9 CD9 molecule
CLDN4 claudin 4
CPB1 carboxypeptidase B1 (tissue)
CTGF connective tissue growth factor
EFNA1 ephrin-A1
EXT1 exostosin glycosyltransferase 1
FTH1 ferritin, heavy polypeptide 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSN gelsolin
HBE1 hemoglobin, epsilon 1
HIST1H1C histone cluster 1, H1c
HOXD1 homeobox D1
IER3 immediate early response 3
INHBA inhibin, beta A
JCHAIN joining chain of multimeric IgA and IgM
JUP junction plakoglobin
KRT18 keratin 18, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LAPTM5 lysosomal protein transmembrane 5
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS8 lectin, galactoside-binding, soluble, 8
LIMCH1 LIM and calponin homology domains 1
LOC100505650 uncharacterized LOC100505650
LXN latexin
MAP7 microtubule-associated protein 7
MEST mesoderm specific transcript
NNMT nicotinamide N-methyltransferase
PFKM phosphofructokinase, muscle
PLK2 polo-like kinase 2
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RTN1 reticulon 1
S100A1 S100 calcium binding protein A1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGK1 serum/glucocorticoid regulated kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SOCS2 suppressor of cytokine signaling 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TMEM30B transmembrane protein 30B
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
C7 complement component 7
CBR3 carbonyl reductase 3
DEFB1 defensin, beta 1
DMD dystrophin
GPM6B glycoprotein M6B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
PLTP phospholipid transfer protein
PRDX2 peroxiredoxin 2
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
Funding