BRD-K23673040_(Naphthalen-1-ylamino)-acetic acid [1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-hydrazide_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-K23673040_(Naphthalen-1-ylamino)-acetic acid [1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-hydrazide_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMPD3 adenosine monophosphate deaminase 3
ANG angiogenin, ribonuclease, RNase A family, 5
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG2 BCL2-associated athanogene 2
BLVRB biliverdin reductase B
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM63A family with sequence similarity 63, member A
FAS Fas cell surface death receptor
FCGBP Fc fragment of IgG binding protein
FGG fibrinogen gamma chain
FHL2 four and a half LIM domains 2
FOXD1 forkhead box D1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IARS isoleucyl-tRNA synthetase
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT23 keratin 23, type I
KRT7 keratin 7, type II
KYNU kynureninase
LBH limb bud and heart development
MCUR1 mitochondrial calcium uniporter regulator 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTA1 metastasis associated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NQO1 NAD(P)H dehydrogenase, quinone 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PELO pelota homolog (Drosophila)
PENK proenkephalin
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PSD3 pleckstrin and Sec7 domain containing 3
PTPRC protein tyrosine phosphatase, receptor type, C
RABGGTB Rab geranylgeranyltransferase, beta subunit
RGCC regulator of cell cycle
RNASE4 ribonuclease, RNase A family, 4
RNF114 ring finger protein 114
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC16A6 solute carrier family 16, member 6
SLC35G2 solute carrier family 35, member G2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TM4SF1 transmembrane 4 L six family member 1
TMEM41B transmembrane protein 41B
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
AKAP7 A kinase (PRKA) anchor protein 7
ANXA3 annexin A3
ASRGL1 asparaginase like 1
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDCA3 cell division cycle associated 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COL3A1 collagen, type III, alpha 1
COL4A2 collagen, type IV, alpha 2
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CST3 cystatin C
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EID1 EP300 interacting inhibitor of differentiation 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM111A family with sequence similarity 111, member A
FAM64A family with sequence similarity 64, member A
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GBP1 guanylate binding protein 1, interferon-inducible
GOLM1 golgi membrane protein 1
GTSE1 G-2 and S-phase expressed 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LGALS1 lectin, galactoside-binding, soluble, 1
LMNB2 lamin B2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MKI67 marker of proliferation Ki-67
NCAPD2 non-SMC condensin I complex, subunit D2
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NLGN4X neuroligin 4, X-linked
NOTCH2 notch 2
NUSAP1 nucleolar and spindle associated protein 1
OLFM1 olfactomedin 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
SAMHD1 SAM domain and HD domain 1
SET SET nuclear proto-oncogene
SFTPA2 surfactant protein A2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORBS1 sorbin and SH3 domain containing 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX2 SRY (sex determining region Y)-box 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF6 serine/arginine-rich splicing factor 6
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCF4 transcription factor 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPSAB1 tryptase alpha/beta 1
TPX2 TPX2, microtubule-associated
TUBB4B tubulin, beta 4B class IVb
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican
XIST X inactive specific transcript (non-protein coding)
Funding