BRD-K23673040_(Naphthalen-1-ylamino)-acetic acid [1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-hydrazide_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K23673040_(Naphthalen-1-ylamino)-acetic acid [1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-hydrazide_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
ASNS asparagine synthetase (glutamine-hydrolyzing)
C1S complement component 1, s subcomponent
CBR1 carbonyl reductase 1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
COL14A1 collagen, type XIV, alpha 1
COL2A1 collagen, type II, alpha 1
COMP cartilage oligomeric matrix protein
CTSL cathepsin L
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
ELOVL5 ELOVL fatty acid elongase 5
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
GAL galanin/GMAP prepropeptide
GDF15 growth differentiation factor 15
GPX7 glutathione peroxidase 7
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IGFBP5 insulin-like growth factor binding protein 5
IL11 interleukin 11
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA1598
KRT18 keratin 18, type I
KRT23 keratin 23, type I
KYNU kynureninase
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
MAP1B microtubule-associated protein 1B
MMP3 matrix metallopeptidase 3
MUC4 mucin 4, cell surface associated
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDGFA platelet-derived growth factor alpha polypeptide
PENK proenkephalin
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTGES prostaglandin E synthase
RBP1 retinol binding protein 1, cellular
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMOX spermine oxidase
SORBS2 sorbin and SH3 domain containing 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
SRPX2 sushi-repeat containing protein, X-linked 2
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1

decreased expression

Symbol Name
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AURKA aurora kinase A
BCHE butyrylcholinesterase
CCNB2 cyclin B2
CPA3 carboxypeptidase A3 (mast cell)
CSNK2A1 casein kinase 2, alpha 1 polypeptide
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DMD dystrophin
EFNB2 ephrin-B2
ENO3 enolase 3 (beta, muscle)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FLRT3 fibronectin leucine rich transmembrane protein 3
GATA2 GATA binding protein 2
HACD1 3-hydroxyacyl-CoA dehydratase 1
HES1 hes family bHLH transcription factor 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPB1 heat shock 27kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
LOXL1 lysyl oxidase-like 1
LYPLA1 lysophospholipase I
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MTA1 metastasis associated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRIP1 nuclear receptor interacting protein 1
PDGFC platelet derived growth factor C
PODXL podocalyxin-like
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
RSRP1 arginine/serine-rich protein 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SESN1 sestrin 1
SFTPB surfactant protein B
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN13 tetraspanin 13
ZBTB18 zinc finger and BTB domain containing 18
ZMYND8 zinc finger, MYND-type containing 8
Funding