BRD-K24050847_KIN001-270_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K24050847_KIN001-270_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ALOX5 arachidonate 5-lipoxygenase
ASS1 argininosuccinate synthase 1
BCL2A1 BCL2-related protein A1
BMP2 bone morphogenetic protein 2
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CCL20 chemokine (C-C motif) ligand 20
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CTSB cathepsin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSP desmoplakin
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FRZB frizzled-related protein
FTH1 ferritin, heavy polypeptide 1
GAL galanin/GMAP prepropeptide
IGKV4-1 immunoglobulin kappa variable 4-1
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
KLF6 Kruppel-like factor 6
LAMP3 lysosomal-associated membrane protein 3
LIMCH1 LIM and calponin homology domains 1
MAB21L2 mab-21-like 2 (C. elegans)
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NELL2 NEL-like 2 (chicken)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PI3 peptidase inhibitor 3, skin-derived
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PSIP1 PC4 and SFRS1 interacting protein 1
PTN pleiotrophin
RGCC regulator of cell cycle
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SLC38A1 solute carrier family 38, member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SRGN serglycin
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STC2 stanniocalcin 2
TDO2 tryptophan 2,3-dioxygenase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFRC transferrin receptor
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TUBB2B tubulin, beta 2B class IIb
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIRF adipogenesis regulatory factor
ARID4B AT rich interactive domain 4B (RBP1-like)
CCND2 cyclin D2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CGRRF1 cell growth regulator with ring finger domain 1
CTSH cathepsin H
CYR61 cysteine-rich, angiogenic inducer, 61
ERBB4 erb-b2 receptor tyrosine kinase 4
ETV1 ets variant 1
FGF13 fibroblast growth factor 13
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
HIST1H4C histone cluster 1, H4c
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
NBPF10 neuroblastoma breakpoint family, member 10
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFC platelet derived growth factor C
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RFC2 replication factor C (activator 1) 2, 40kDa
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
STAR steroidogenic acute regulatory protein
TFF1 trefoil factor 1