BRD-K24132293_piperlongumine (HPLC)_AGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

250 genes differentially expressed following the BRD-K24132293_piperlongumine (HPLC)_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ADM adrenomedullin
AEBP1 AE binding protein 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPT2 angiopoietin 2
ANPEP alanyl (membrane) aminopeptidase
ARC activity-regulated cytoskeleton-associated protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATG12 autophagy related 12
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
AZIN1 antizyme inhibitor 1
BAG3 BCL2-associated athanogene 3
BCHE butyrylcholinesterase
BGN biglycan
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CALR calreticulin
CANX calnexin
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CD52 CD52 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CECR1 cat eye syndrome chromosome region, candidate 1
CFAP20 cilia and flagella associated protein 20
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLU clusterin
CNN3 calponin 3, acidic
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSK cathepsin K
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIO1 deiodinase, iodothyronine, type I
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDN3 endothelin 3
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
EZR ezrin
FABP7 fatty acid binding protein 7, brain
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GOLM1 golgi membrane protein 1
GSTA1 glutathione S-transferase alpha 1
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
KCTD5 potassium channel tetramerization domain containing 5
KLHL21 kelch-like family member 21
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LEF1 lymphoid enhancer-binding factor 1
LOC100272216 uncharacterized LOC100272216
LOC100505650 uncharacterized LOC100505650
LUC7L3 LUC7-like 3 (S. cerevisiae)
MMP11 matrix metallopeptidase 11
MPO myeloperoxidase
MTSS1 metastasis suppressor 1
NARFL nuclear prelamin A recognition factor-like
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NBPF10 neuroblastoma breakpoint family, member 10
NEB nebulin
NEFL neurofilament, light polypeptide
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
OSER1 oxidative stress responsive serine-rich 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POU4F1 POU class 4 homeobox 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRTN3 proteinase 3
RAD21 RAD21 homolog (S. pombe)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SELE selectin E
SERINC1 serine incorporator 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
SULF1 sulfatase 1
TBC1D31 TBC1 domain family, member 31
TCF4 transcription factor 4
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52 tumor protein D52
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
VIM vimentin
WSB1 WD repeat and SOCS box containing 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF264 zinc finger protein 264
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ALOX5 arachidonate 5-lipoxygenase
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BHLHE40 basic helix-loop-helix family, member e40
BLCAP bladder cancer associated protein
CALB1 calbindin 1, 28kDa
CCKBR cholecystokinin B receptor
CCNA2 cyclin A2
CCND1 cyclin D1
CDCA4 cell division cycle associated 4
CHN2 chimerin 2
CLDN18 claudin 18
CLIC3 chloride intracellular channel 3
COA3 cytochrome c oxidase assembly factor 3
CSE1L CSE1 chromosome segregation 1-like (yeast)
CST3 cystatin C
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DLC1 DLC1 Rho GTPase activating protein
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP4 dual specificity phosphatase 4
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOSC4 exosome component 4
FAM63A family with sequence similarity 63, member A
FOXA2 forkhead box A2
GALE UDP-galactose-4-epimerase
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HES1 hes family bHLH transcription factor 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
JADE2 jade family PHD finger 2
KHNYN KH and NYN domain containing
KIAA0391 KIAA0391
KLC1 kinesin light chain 1
KRT18 keratin 18, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTBP1 latent transforming growth factor beta binding protein 1
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MICALL1 MICAL-like 1
MRPS2 mitochondrial ribosomal protein S2
MSL1 male-specific lethal 1 homolog (Drosophila)
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NELFB negative elongation factor complex member B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLSCR3 phospholipid scramblase 3
PMPCA peptidase (mitochondrial processing) alpha
PPAP2C phosphatidic acid phosphatase type 2C
PPARG peroxisome proliferator-activated receptor gamma
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTGES prostaglandin E synthase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBPMS RNA binding protein with multiple splicing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFTPB surfactant protein B
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMAD3 SMAD family member 3
SOCS2 suppressor of cytokine signaling 2
SPATA20 spermatogenesis associated 20
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TBCD tubulin folding cofactor D
TESC tescalcin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TMEM164 transmembrane protein 164
TNS3 tensin 3
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
Funding