BRD-K25690923_-666_COV644_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K25690923_-666_COV644_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APOC1 apolipoprotein C-I
ASPN asporin
CEP57 centrosomal protein 57kDa
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
CPE carboxypeptidase E
CRIP2 cysteine-rich protein 2
DCN decorin
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
LUM lumican
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMD monocyte to macrophage differentiation-associated
NR4A2 nuclear receptor subfamily 4, group A, member 2
OBSL1 obscurin-like 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM1 PDZ and LIM domain 1
PDLIM3 PDZ and LIM domain 3
PEG3 paternally expressed 3
POSTN periostin, osteoblast specific factor
RAD21 RAD21 homolog (S. pombe)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SLC38A2 solute carrier family 38, member 2
SOX17 SRY (sex determining region Y)-box 17
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCEAL2 transcription elongation factor A (SII)-like 2
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZIC1 Zic family member 1
ZNF331 zinc finger protein 331
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ADGRG2 adhesion G protein-coupled receptor G2
AHNAK2 AHNAK nucleoprotein 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA6 annexin A6
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BAD BCL2-associated agonist of cell death
CD151 CD151 molecule (Raph blood group)
CD24 CD24 molecule
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FHL2 four and a half LIM domains 2
FLNB filamin B, beta
FOXJ3 forkhead box J3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPX3 glutathione peroxidase 3
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IL6ST interleukin 6 signal transducer
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM5D lysine (K)-specific demethylase 5D
KLHL21 kelch-like family member 21
KPNB1 karyopherin (importin) beta 1
KRT15 keratin 15, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTBP3 latent transforming growth factor beta binding protein 3
LY6E lymphocyte antigen 6 complex, locus E
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MSRB2 methionine sulfoxide reductase B2
MYCBP MYC binding protein
NPC2 Niemann-Pick disease, type C2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLEC plectin
PNMA1 paraneoplastic Ma antigen 1
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
PUF60 poly-U binding splicing factor 60KDa
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLIRP SRA stem-loop interacting RNA binding protein
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SUB1 SUB1 homolog (S. cerevisiae)
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMED3 transmembrane emp24 protein transport domain containing 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNIP1 TNFAIP3 interacting protein 1
TPM1 tropomyosin 1 (alpha)
TSPAN3 tetraspanin 3
WDTC1 WD and tetratricopeptide repeats 1
Funding