BRD-K25737009_-666_A673_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K25737009_-666_A673_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA1 annexin A1
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHMP4A charged multivesicular body protein 4A
CPA3 carboxypeptidase A3 (mast cell)
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DARS aspartyl-tRNA synthetase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FKBP11 FK506 binding protein 11, 19 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNMT histamine N-methyltransferase
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
INHBE inhibin, beta E
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KYNU kynureninase
LITAF lipopolysaccharide-induced TNF factor
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MSMB microseminoprotein, beta-
MZB1 marginal zone B and B1 cell-specific protein
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
POU2AF1 POU class 2 associating factor 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SIK1 salt-inducible kinase 1
SLAMF7 SLAM family member 7
SLC35F2 solute carrier family 35, member F2
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF7 serine/arginine-rich splicing factor 7
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TP63 tumor protein p63
TRA2A transformer 2 alpha homolog (Drosophila)
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UBE2B ubiquitin-conjugating enzyme E2B
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AKAP7 A kinase (PRKA) anchor protein 7
APMAP adipocyte plasma membrane associated protein
ASPN asporin
C2CD5 C2 calcium-dependent domain containing 5
CANT1 calcium activated nucleotidase 1
CCNF cyclin F
CDC20 cell division cycle 20
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
COL10A1 collagen, type X, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYTL1 cytokine-like 1
DHCR24 24-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DUSP7 dual specificity phosphatase 7
ECH1 enoyl CoA hydratase 1, peroxisomal
FAP fibroblast activation protein, alpha
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GJA1 gap junction protein, alpha 1, 43kDa
HMGB3 high mobility group box 3
ICMT isoprenylcysteine carboxyl methyltransferase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LAPTM4B lysosomal protein transmembrane 4 beta
MAGED1 melanoma antigen family D1
MAN2B1 mannosidase, alpha, class 2B, member 1
MMP11 matrix metallopeptidase 11
NREP neuronal regeneration related protein
NUP210 nucleoporin 210kDa
PDLIM2 PDZ and LIM domain 2 (mystique)
PODXL podocalyxin-like
PON2 paraoxonase 2
PSRC1 proline/serine-rich coiled-coil 1
RGS4 regulator of G-protein signaling 4
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TAGLN transgelin
TNNT1 troponin T type 1 (skeletal, slow)
TRIM14 tripartite motif containing 14
VGLL4 vestigial-like family member 4
Funding