BRD-K25737009_-666_HEC108_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K25737009_-666_HEC108_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC2 baculoviral IAP repeat containing 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC7A C-type lectin domain family 7, member A
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
ELOVL5 ELOVL fatty acid elongase 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM129A family with sequence similarity 129, member A
FGFR2 fibroblast growth factor receptor 2
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GTPBP2 GTP binding protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
OPN3 opsin 3
PARP8 poly (ADP-ribose) polymerase family, member 8
PILRB paired immunoglobin-like type 2 receptor beta
PPAP2B phosphatidic acid phosphatase type 2B
PPOX protoporphyrinogen oxidase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RTN1 reticulon 1
SGK1 serum/glucocorticoid regulated kinase 1
STX1A syntaxin 1A (brain)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAGLN2 transgelin 2
THBD thrombomodulin
TLR2 toll-like receptor 2
TXNRD1 thioredoxin reductase 1
VNN1 vanin 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
B3GNT1
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CCNF cyclin F
CD99 CD99 molecule
DAPK1 death-associated protein kinase 1
FAM57A family with sequence similarity 57, member A
FKBP10 FK506 binding protein 10, 65 kDa
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GOLM1 golgi membrane protein 1
HOXA10 homeobox A10
HOXC6 homeobox C6
KANK2 KN motif and ankyrin repeat domains 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KRT7 keratin 7, type II
LRP5 low density lipoprotein receptor-related protein 5
MAL mal, T-cell differentiation protein
METRN meteorin, glial cell differentiation regulator
NT5DC2 5'-nucleotidase domain containing 2
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM2 PDZ and LIM domain 2 (mystique)
PFN2 profilin 2
PLK1 polo-like kinase 1
RPS11 ribosomal protein S11
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
STK32B serine/threonine kinase 32B
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TMEM2 transmembrane protein 2
Funding