BRD-K25737009_-666_HEPG2_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K25737009_-666_HEPG2_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BACE2 beta-site APP-cleaving enzyme 2
BGN biglycan
BRD4 bromodomain containing 4
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNOT4 CCR4-NOT transcription complex, subunit 4
CRABP1 cellular retinoic acid binding protein 1
EGR1 early growth response 1
GADD45B growth arrest and DNA-damage-inducible, beta
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IGLL1 immunoglobulin lambda-like polypeptide 1
JUN jun proto-oncogene
LEF1 lymphoid enhancer-binding factor 1
NOTCH1 notch 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PDLIM3 PDZ and LIM domain 3
PERP PERP, TP53 apoptosis effector
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PRRC2C proline-rich coiled-coil 2C
PRTN3 proteinase 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP4 secreted frizzled-related protein 4
SRGN serglycin
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TMPRSS3 transmembrane protease, serine 3
TPBG trophoblast glycoprotein
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
C20ORF24 chromosome 20 open reading frame 24
CKB creatine kinase, brain
CORO1C coronin, actin binding protein, 1C
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL14 chemokine (C-X-C motif) ligand 14
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF6 eukaryotic translation initiation factor 6
FADS1 fatty acid desaturase 1
FAM57A family with sequence similarity 57, member A
FGG fibrinogen gamma chain
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
HAT1 histone acetyltransferase 1
HOPX HOP homeobox
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK13 mitogen-activated protein kinase 13
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
NCOA4 nuclear receptor coactivator 4
PPIF peptidylprolyl isomerase F
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SORD sorbitol dehydrogenase
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
Funding