BRD-K25737009_-666_NCIH596_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K25737009_-666_NCIH596_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ACP5 acid phosphatase 5, tartrate resistant
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARL4A ADP-ribosylation factor-like 4A
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BIRC2 baculoviral IAP repeat containing 2
BLNK B-cell linker
BTG3 BTG family, member 3
CA1 carbonic anhydrase I
CCL13 chemokine (C-C motif) ligand 13
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHGB chromogranin B
CHIC2 cysteine-rich hydrophobic domain 2
CLEC3B C-type lectin domain family 3, member B
CLIC4 chloride intracellular channel 4
CREB3L2 cAMP responsive element binding protein 3-like 2
CREM cAMP responsive element modulator
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT6B keratin 6B, type II
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MAPK13 mitogen-activated protein kinase 13
MCL1 myeloid cell leukemia 1
MCOLN1 mucolipin 1
MFAP5 microfibrillar associated protein 5
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PON3 paraoxonase 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSME4 proteasome (prosome, macropain) activator subunit 4
RAB38 RAB38, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNF167 ring finger protein 167
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SEC61B Sec61 beta subunit
SEPP1 selenoprotein P, plasma, 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SPATS2L spermatogenesis associated, serine-rich 2-like
STX1A syntaxin 1A (brain)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
VAMP8 vesicle-associated membrane protein 8
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM10 ADAM metallopeptidase domain 10
ADD3 adducin 3 (gamma)
AKR1C2 aldo-keto reductase family 1, member C2
APOL1 apolipoprotein L, 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
B3GNT1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C2CD5 C2 calcium-dependent domain containing 5
CCNA2 cyclin A2
CCNG1 cyclin G1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP22 dual specificity phosphatase 22
ENO2 enolase 2 (gamma, neuronal)
EXOSC4 exosome component 4
F12 coagulation factor XII (Hageman factor)
FASN fatty acid synthase
GAS1 growth arrest-specific 1
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPC1 glypican 1
GYG2 glycogenin 2
HEG1 heart development protein with EGF-like domains 1
HLTF helicase-like transcription factor
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
IFITM2 interferon induced transmembrane protein 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KANK1 KN motif and ankyrin repeat domains 1
KRT19 keratin 19, type I
LAMA4 laminin, alpha 4
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBH limb bud and heart development
MARCKSL1 MARCKS-like 1
MNDA myeloid cell nuclear differentiation antigen
MRPS2 mitochondrial ribosomal protein S2
NQO1 NAD(P)H dehydrogenase, quinone 1
NXN nucleoredoxin
PCGF2 polycomb group ring finger 2
PFN2 profilin 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SET SET nuclear proto-oncogene
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SULF1 sulfatase 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TKT transketolase
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPM2 tropomyosin 2 (beta)
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Funding